Phenotypes associated with this allele

• Allele Symbol: Tg(APP-App*R609D*K612E)7Vln
• Allele Name: transgene insertion 7, Fred Van Leuven
• Allele ID: MGI:3720083
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(APP-App*R609D*K612E)7Vln/0	involves: FVB	MGI:3720108

Genotype
MGI:3720108

tg1

• Allelic Composition: Tg(APP-App*R609D*K612E)7Vln/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:32213 )

• numerous apoptotic cells are observed in the amygdala

abnormal neuron morphology ( J:32213 )

• neurons in the brain appear abnormal upon post-mortem; many are vacuolized, or contain clear cytoplasm around compacted and densely stained nuclei, and are usually found on the boundary of the granule layer and hilus of dentate gyrus and throughout granule layer of dentate gyrus

neuron degeneration ( J:32213 )

• degenerating neurons are present in thalamus and posterior cingulate cortex, caudate putamen, hypothalamus and CA1 and CA2 region of pyramidal layer of hippocampus

cellular

increased neuron apoptosis ( J:32213 )

• numerous apoptotic cells are observed in the amygdala