Phenotypes associated with this allele

• Allele Symbol: Hdac2^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:3717927
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hdac2^tm1.1Eno/Hdac2^tm1.1Eno H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129 * C57BL/6 * CBA	MGI:3851919
cn2	Hdac2^tm1.1Eno/Hdac2^tm1.1Eno Tg(Myh6-cre)2182Mds/?	involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	MGI:3718387
cn3	Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Hdac2^tm1.1Eno/Hdac2^tm1.1Eno Tg(Myh6-cre)2182Mds/?	involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	MGI:3718388
cn4	Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Hdac2^tm1.1Eno/Hdac2^+ Tg(KRT14-cre)1Ipc/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:5605729

Genotype
MGI:3851919

cn1

• Allelic Composition: Hdac2^tm1.1Eno/Hdac2^tm1.1Eno; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:150709 )

• no abnormal phenotype is detected in skull development

Genotype
MGI:3718387

cn2

• Allelic Composition: Hdac2^tm1.1Eno/Hdac2^tm1.1Eno; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

normal phenotype

no abnormal phenotype detected ( J:123173 )

• mice are viable into adulthood and show no cardiac abnormalities

Genotype
MGI:3718388

cn3

• Allelic Composition: Hdac1^tm1.1Eno/Hdac1^tm1.1Eno; Hdac2^tm1.1Eno/Hdac2^tm1.1Eno; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

mortality/aging

postnatal lethality, incomplete penetrance ( J:123173 )

• mice die by day 14

cardiovascular system

dilated heart ventricle ( J:123173 )

• at P11, left and right ventricles are dilated

irregular heartbeat ( J:123173 )

• at P10, mice display cardiac arrhythmias

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

muscle

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

cellular

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

Genotype
MGI:5605729

cn4

• Allelic Composition: Hdac1^tm1.1Eno/Hdac1^tm1.1Eno; Hdac2^tm1.1Eno/Hdac2⁺; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

integument

abnormal coat appearance ( J:205733 )

• double mutants show similar but more obvious hair and skin phenotypes than single Hdac1 conditional homozygotes

• characteristic hair types are replaced by abnormally pigmented, shorter, thinner hairs with misshaped and twisted medulla structures

abnormal nail morphology ( J:205733 )

• mice show more severe supernumerary claw phenotypes than single Hdac1 conditional homozygotes

abnormal nail color ( J:205733 )

• mice show more severe pigmentation in the claws than single Hdac1 conditional homozygotes

abnormal vibrissa morphology ( J:205733 )

• vibrissa hair fiber thickness and length are reduced

short vibrissae ( J:205733 )

abnormal epidermal layer morphology ( J:205733 )

• interfollicular epithelium is hyperpigmented

hyperkeratosis ( J:205733 )

• foot skin epithelium is hyperkeratotic

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

limbs/digits/tail

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

pigmentation

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

vision/eye

narrow eye opening ( J:205733 )