Analysis Tools
normal phenotype
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• no abnormal phenotype is detected in skull development
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Allele Symbol Allele Name Allele ID |
Hdac1tm1.1Eno targeted mutation 1.1, Eric N Olson MGI:3717923 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no abnormal phenotype is detected in skull development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are phenotypically normal and have no cardiac abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by day 14
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• at P11, left and right ventricles are dilated
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• at P10, mice display cardiac arrhythmias
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• mice have a three-fold increase in apoptosis compared to wild-type and control mice
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• mice have a three-fold increase in apoptosis compared to wild-type and control mice
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• mice have a three-fold increase in apoptosis compared to wild-type and control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants show similar but more obvious hair and skin phenotypes than single Hdac1 conditional homozygotes
• characteristic hair types are replaced by abnormally pigmented, shorter, thinner hairs with misshaped and twisted medulla structures
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• mice show more severe supernumerary claw phenotypes than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation in the claws than single Hdac1 conditional homozygotes
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• vibrissa hair fiber thickness and length are reduced
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• interfollicular epithelium is hyperpigmented
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• foot skin epithelium is hyperkeratotic
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• periorbital area shows normal eyelashes but pelage hair numbers are reduced and hair pattern is disrupted
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• periorbital area shows normal eyelashes but pelage hair numbers are reduced and hair pattern is disrupted
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• epithelial cyst-like structures on the dorsal skin of adults
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• at 6 months of age
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• lipid-retaining cells are increased in sebaceous glands
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• Meibomian glands are hyperplastic
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• epithelial cyst-like structures on the dorsal skin of adults
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• characteristic hair types are replaced by abnormally pigmented, shorter, thinner hairs with misshaped and twisted medulla structures
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• extensive alopecia on the dorsal skin of adults
• alopecia appears during the first hair cycle and does not progress to open lesions, ulcers, or scarring
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• ingrown hair fibers
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• hair medulla is abnormal with misaligned air cells
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• affected follicles of mutants have only one hair type that resembles abnormal zigzag hair
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• paws exhibit supernumerary claws that form on the lateral sides of digits
• claw dystrophies include unique outgrowths of the hyponychium that extends beyond the claw matrix
• supernumerary claw matrices are covered with compact keratin structures extending from the proximal claw fold
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• pigmentation is increased in the claws
• hyperpigmentation is due to the presence of ectopic pigmented melanocytes in the dermal-epidermal junction in the claw matrix
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• presence of ectopic pigmented melanocytes in the dermal-epidermal junction in the claw matrix
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• hair follicle dystrophy on the dorsal skin of adults; prevalence is similar at 3 and 6 months of age
• skin and hair appear normal at P9, however dystrophic hair follicle cysts begin to form by 3 weeks of age and become prevalent by 3 months
• dystrophic follicle cysts form from hair follicle progenitor cells that fail to differentiate properly
• coiled hair follicles
• lipid-retaining cells are increased in tail hair follicles
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• dystrophic follicle cysts form from hair follicle progenitor cells that fail to differentiate properly
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• dilated infundibulae on the dorsal skin of adults
• enlarged infundibula of dystrophic follicles sometimes contains keratin arranged in columns resembling a hair shaft and others that contain keratin with less structure
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• hair follicle orientation is abnormal, with fibers pointing towards the dermis instead of the epithelium
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• disrupted hair follicle alignment
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• vibrissa hair fiber thickness and length are reduced
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• interfollicular epithelium is hyperpigmented
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• apoptosis is increased in the epidermal basal layer of the interfollicular skin at 6 months of age
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• hyperkeratosis is seen at 6 months of age
• foot skin epithelium is hyperkeratotic
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• dystrophic follicular epithelium is often stratified without a significant granular layer
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• keratinocytes in all layers are variable in cell size and shape
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• marker analysis indicates that hair differentiation is disrupted in KRT14-producing keratinocytes, however epidermal differentiation is maintained but control of homeostasis is disrupted
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• moderate epidermal hyperplasia is seen at 6 months of age
• hyperplastic epidermis in the tail skin
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• pigmentation is increased in the foot pads and feet
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• tail skin shows a nonautonomous increase of pigment cells
• increase in number of melanoblasts in the interscale region of the tail
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• marker analysis indicates that hair differentiation is disrupted in KRT14-producing keratinocytes, however epidermal differentiation is maintained but control of homeostasis is disrupted
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• lipid-retaining cells are increased in sebaceous glands
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• Meibomian glands are hyperplastic
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• pigmentation is increased in the foot pads and feet
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• the tail skin exhibits hyperkeratosis, hyperpigmentation, a reduction in normal hair, and an increase of lipid retaining cells
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• tail skin shows a nonautonomous increase of pigment cells
• increase in number of melanoblasts in the interscale region of the tail
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• pigmentation is increased in the foot pads and feet
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• tail skin shows a nonautonomous increase of pigment cells
• increase in number of melanoblasts in the interscale region of the tail
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• hyperpigmentation is due to the presence of ectopic pigmented melanocytes in the dermal-epidermal junction in the claw matrix
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• enlarged eyelids
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• Meibomian glands are hyperplastic
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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