All Phenotypes Tctn1<Gt(KST296)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tctn1^{Gt(KST296)Byg}
gene trap KST296, BayGenomics
MGI:3716885

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}	B6.129P2-Tctn1^{Gt(KST296)Byg}	MGI:3717154
hm2	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}	involves: 129P2/OlaHsd	MGI:5292229
cx3	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Tmem67^tm1Dgen/Tmem67^tm1Dgen	B6.129P2-Tmem67^tm1Dgen Tctn1^{Gt(KST296)Byg}	MGI:5292227
cx4	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Shh^tm1Chg/Shh^tm1Chg	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3717155
cx5	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Smo^tm1Amc/Smo^tm1Amc	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3717156

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}
Genetic Background	B6.129P2-Tctn1^{Gt(KST296)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:103820 )

• mice die between E13.4 and E16.5

nervous system

absent floor plate ( J:103820 )

small embryonic telencephalon ( J:103820 )

• telencephalon is smaller than in wild-type mice

holoprosencephaly ( J:103820 )

embryo

absent floor plate ( J:103820 )

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:176174 )

N	• cilia forms in the notochord and limb bud mesenchymal

absent embryonic cilia ( J:176174 )

• at E8.5

abnormal left-right axis patterning ( J:176174 )

• mice exhibit disrupted nodal flow and left lateral plate induction of Nodal gene expression compared with wild-type mice

abnormal rostral-caudal axis patterning ( J:176174 )

• variable curvature

abnormal embryonic neuroepithelium morphology ( J:176174 )

• at E10.5, cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

nervous system

abnormal embryonic neuroepithelium morphology ( J:176174 )

• at E10.5, cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

limbs/digits/tail

preaxial polydactyly ( J:176174 )

• in the hindlimb

cellular

cellular phenotype ( J:176174 )

N	• mouse embryonic fibroblasts develop cilia

absent embryonic cilia ( J:176174 )

• at E8.5

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Tmem67^tm1Dgen/Tmem67^tm1Dgen
Genetic Background	B6.129P2-Tmem67^tm1Dgen Tctn1^{Gt(KST296)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (30 available)
Tmem67^tm1Dgen mutation (2 available); any Tmem67 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic tissue morphology ( J:176174 )

• mice exhibit the same defects as in Tctn1^{Gt(KST296)Byg} homozygotes

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Shh^tm1Chg/Shh^tm1Chg
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased forebrain size ( J:103820 )

• forebrains are larger than in Shh^tm1Chg

Allelic Composition	Tctn1^{Gt(KST296)Byg}/Tctn1^{Gt(KST296)Byg} Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smo^tm1Amc mutation (1 available); any Smo mutation (44 available)
Tctn1^{Gt(KST296)Byg} mutation (0 available); any Tctn1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased forebrain size ( J:103820 )

• forebrains are larger than in Smo^tm1Amc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24