All Phenotypes Shc1<tm9Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm9Paw
targeted mutation 9, Tony Pawson
MGI:3716783

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717100
cn2	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717101
cn3	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm9Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717102
cn4	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm3Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717104
cn5	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717105
cn6	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm7Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717106
cn7	Shc1^tm9Paw/Shc1^tm9Paw Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4361923

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (38 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122927 )

• mutants appear normal

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (38 available)
Shc1^tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122927 )

• mutants appear normal

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm9Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• all viable mice are severely uncoordinated, appearing similar to Shc1^tm4Paw homozygotes

ataxia ( J:122927 )

impaired limb coordination ( J:122927 )

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls

• intrafusal fiber numbers are 59% that of controls

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls

• intrafusal fiber numbers are 59% that of controls

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm3Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are similar to those observed in Shc1^tm7Paw homozygotes

impaired limb coordination ( J:122927 )

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are less severe, similar to those observed in Shc1^tm4Paw homozygotes

ataxia ( J:122927 )

muscle

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm7Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm7Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are similar to those observed in Shc1^tm7Paw homozygotes

ataxia ( J:122927 )

impaired limb coordination ( J:122927 )

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

Allelic Composition	Shc1^tm9Paw/Shc1^tm9Paw Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-Erbb2*,-cre)1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:133325 )

N	• mammary tumor development is completely ablated

reproductive system

reproductive system phenotype ( J:133325 )

N	• mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells mammary glands show no hyperplastic or neoplastic lesions within mammary epithelial cells

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

integument

abnormal mammary gland morphology ( J:133325 )

• compared to wild-type FVB controls, proliferative index of mammary epithelial cells is strongly reduced and apoptotic index is significantly increased

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