Analysis Tools
nervous system
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• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size
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Allele Symbol Allele Name Allele ID |
Gsctm2Bhr targeted mutation 2, Richard R Behringer MGI:3716759 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 75% of embryos at E7.5 - E9.5 display abnormalities that vary in severity
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• at E8.5 and E9.5 variable truncations of the forebrain are seen ranging from mild reduction in head size (14.3% of embryos) to partial loss of the forebrain and ill-defined brain segments (42.8%) and in severely affected embryos (14.3%) anterior truncations resembling those in Dkk1 single homozygotes
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• poor development of the eye primordium in moderately affected embryos (42.8%)
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• at E8.5 - E9.5, head size is reduced by 16% compared to wild-type
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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