Phenotypes associated with this allele

• Allele Symbol: Hsd3b7^tm1Rus
• Allele Name: targeted mutation 1 David W Russell
• Allele ID: MGI:3716711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd3b7^tm1Rus/Hsd3b7^tm1Rus	involves: 129S/SvEv * C57BL/6J	MGI:3717268

Genotype
MGI:3717268

hm1

• Allelic Composition: Hsd3b7^tm1Rus/Hsd3b7^tm1Rus
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotypes of Hsd3b7^tm1Rus/Hsd3b7^tm1Rus mice

mortality/aging

postnatal lethality, complete penetrance ( J:122973 )

• nearly all mice die within the first 18 days after birth

• survival is increased with pan-vitamin and dietary bile acid supplements

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:122973 )

• intestinal cholesterol absorption is decreased to less than 9%

decreased circulating triglyceride level ( J:122973 )

• serum triglyceride levels are decreased 32%

abnormal bile salt homeostasis ( J:122973 )

• bile acids in stool are increased by 2%

• fecal neutral sterol secretion is increased by 2.8-fold

abnormal cholesterol homeostasis ( J:122973 )

• cholesterol biosynthesis is decreased modestly in the kidney

• cholesterol biosynthesis is increased 3.5-fold in the liver with smaller increases in the duodenal and jejunal segments of the small intestine

increased fatty acids level ( J:122973 )

• fatty acid biosynthesis is increased in the liver by 20%

increased liver triglyceride level ( J:122973 )

• hepatic triglyceride levels are increased 30%

growth/size/body

postnatal growth retardation ( J:122973 )

digestive/alimentary system

decreased intestinal cholesterol absorption ( J:122973 )

• intestinal cholesterol absorption is decreased to less than 9%

liver/biliary system

increased liver triglyceride level ( J:122973 )

• hepatic triglyceride levels are increased 30%

integument

scaly skin ( J:122973 )

• in unsupplemented suckling and nursing mice

oily skin ( J:122973 )

• in unsupplemented suckling and nursing mice