Phenotypes associated with this allele

• Allele Symbol: Scx^tm1.1Stzr
• Allele Name: targeted mutation 1.1, Ronen Schweitzer
• Allele ID: MGI:3716564
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scx^tm1.1Stzr/Scx^tm1.1Stzr	Not Specified	MGI:3717426
cx2	Scx^tm1.1Stzr/Scx^tm1.1Stzr Tg(Scx-GFP)1Stzr/0	Not Specified	MGI:3717427

Genotype
MGI:3717426

hm1

• Allelic Composition: Scx^tm1.1Stzr/Scx^tm1.1Stzr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal tendon morphology ( J:122742 )

• differentiation and condensation of tendon progenitors is disrupted

• differentiation and elongation of tail tendons is disrupted

• organization of the endotenon and of the tendon matrix is disrupted

abnormal tendon stiffness ( J:122742 )

• forelimb is locked in a dorsal flexure and mice walk on their wrists

• mice cannot grasp railing and tails are completely immobile

behavior/neurological

impaired righting response ( J:122742 )

• mice have a very difficult time turning over

• however, no muscular defects are observed

abnormal tail movements ( J:122742 )

• tails are completely immobile

limbs/digits/tail

absent deltoid tuberosity ( J:122742 )

abnormal tail morphology ( J:122742 )

• differentiation and elongation of tail tendons is disrupted

skeleton

absent deltoid tuberosity ( J:122742 )

abnormal tendon morphology ( J:122742 )

• differentiation and condensation of tendon progenitors is disrupted

• differentiation and elongation of tail tendons is disrupted

• organization of the endotenon and of the tendon matrix is disrupted

abnormal tendon stiffness ( J:122742 )

• forelimb is locked in a dorsal flexure and mice walk on their wrists

• mice cannot grasp railing and tails are completely immobile

Genotype
MGI:3717427

cx2

• Allelic Composition: Scx^tm1.1Stzr/Scx^tm1.1Stzr; Tg(Scx-GFP)1Stzr/0
• Genetic Background: Not Specified

muscle

abnormal tendon morphology ( J:122742 )

• limb tendons are lost with some missing completely and others small and rudimentary

• the extensor digitorium communis tendon ends are the wrist

• the extensor digiti quinti and carpi ulnaris tendons are reduced

• flexor tendons are more severely affected than extensors

• tail tendons are missing

• short tendons in the trunk are reduced or disrupted while long tendons are missing

• intermuscular tendons including the lateral tendious stripes in the rectus abdominis muscle, subscapularis musclea at the ventral side of the scapula, and the middle tendon of the diaphragm can not be detected

• however, anchoring tendons are normal and mice are mobile

behavior/neurological

abnormal tail movements ( J:122742 )

• mice cannot use their tails

limbs/digits/tail

abnormal tail morphology ( J:122742 )

• tail tendons are missing

skeleton

abnormal tendon morphology ( J:122742 )

• limb tendons are lost with some missing completely and others small and rudimentary

• the extensor digitorium communis tendon ends are the wrist

• the extensor digiti quinti and carpi ulnaris tendons are reduced

• flexor tendons are more severely affected than extensors

• tail tendons are missing

• short tendons in the trunk are reduced or disrupted while long tendons are missing

• intermuscular tendons including the lateral tendious stripes in the rectus abdominis muscle, subscapularis musclea at the ventral side of the scapula, and the middle tendon of the diaphragm can not be detected

• however, anchoring tendons are normal and mice are mobile