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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Inpp5dtm1.1Rav
targeted mutation 1.1, Jeffrey V Ravetch
MGI:3715983
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Inpp5dtm1Rav/Inpp5dtm1.1Rav
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3716739


Genotype
MGI:3716739
cn1
Allelic
Composition		 Inpp5dtm1Rav/Inpp5dtm1.1Rav
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1.1Rav mutation (0 available); any Inpp5d mutation (95 available)
Inpp5dtm1Rav mutation (1 available); any Inpp5d mutation (95 available)
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:119256 )
• splenomegaly develops at about 5 weeks of age
absent marginal zone B cells ( J:119256 )
• marginal zone B cells are depleted
abnormal spleen marginal zone macrophage morphology ( J:119256 )
• marginal zone macrophages are reorganized

immune system
enlarged spleen ( J:119256 )
• splenomegaly develops at about 5 weeks of age
absent marginal zone B cells ( J:119256 )
• marginal zone B cells are depleted
abnormal spleen marginal zone macrophage morphology ( J:119256 )
• marginal zone macrophages are reorganized

growth/size/body
enlarged spleen ( J:119256 )
• splenomegaly develops at about 5 weeks of age




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory