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Allele Symbol Allele Name Allele ID |
Glultm1Whla targeted mutation 1, Wouter H Lamers MGI:3715484 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are at sub-Mendelian ratios at E3.5 and none are present at E9.5
• however, culturing embryos with L-glutamine increases survival in culture and proliferation is no different than cultured wild-type embryos
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• mice are at sub-Mendelian ratios at E3.5 and none are present at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are recovered at E8.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 35% increase in branched-chain amino acids
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• muscle glutamine 20-30% lower
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• 20% reduction in plasma glutamine in starved mice
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• detoxification of ammonia is two fold lower
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• faster weight loss when fasting but only for the first 20 hours
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• born in normal numbers
• none found at 6-8 days of age
• death at 2-3 days of age
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• nursed immediately after birth but milk intake then declined
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• moderately elevated brain ammonia levels
• no gross brain malformations
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• decreased alanine in the cortex of the brain at two days of age
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• decreased glutamine in the cortex of the brain at two days of age
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• increased glycine in the cortex of the brain at two days of age
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• moderately elevated brain ammonia levels
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• blood glucose levels at 30% of controls at 2 days of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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