All Phenotypes Tg(Hoxb7-EGFP)33Cos MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hoxb7-EGFP)33Cos
transgene insertion 33, Franklin Costantini
MGI:3715437

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster	MGI:4431231
cn2	Gt(ROSA)26Sor^{tm1(RARA*)Clmd}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster	MGI:4431229
cn3	Ctnnd1^tm1Lfr/Ctnnd1^tm1Lfr Tg(Hoxb7-EGFP)33Cos/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:5439468
cx4	Pax2^1Neu/Pax2⁺ Tg(Hoxb7-EGFP)33Cos/?	involves: 102 * C57BL/6 * CBA * CD-1	MGI:5442587
cx5	Robo2^tm1.1Rilm/Robo2⁺ Tg(Hoxb7-EGFP)33Cos/?	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:3759463
cx6	Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3767253
cx7	Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3767254
cx8	Bmp4^tm3.2Blh/Bmp4⁺ Grem1^tm1Azun/Grem1^tm1Azun Tg(Hoxb7-EGFP)33Cos/?	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA	MGI:3715256
cx9	Bmp4^tm3.2Blh/Bmp4^tm3.2Blh Grem1^tm1Azun/Grem1^tm1Azun Tg(Hoxb7-EGFP)33Cos/?	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA	MGI:3715257
cx10	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Tg(Hoxb7-EGFP)33Cos/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster	MGI:4431234
cx11	Sema3a^tm1Mcf/Sema3a^tm1Mcf Tg(Hoxb7-EGFP)33Cos/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5435265
tg12	Tg(Hoxb7-EGFP)33Cos/0	involves: C57BL/6 * CBA	MGI:3715525

Allelic Composition	Gt(ROSA)26Sor^{tm1(RARA)Clmd}/Gt(ROSA)26Sor^{tm1(RARA)Clmd} Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(RARA*)Clmd} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• severe renal hypoplasia with reduced branching at E14

absent kidney ( J:157254 )

• renal agenesis at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• barely begin to branch at E11

• severe renal hypoplasia with reduced branching at E14

small ureteric bud ( J:157254 )

• smaller ureteric bud at E10.5 than in normal embryos

Allelic Composition	Gt(ROSA)26Sor^{tm1(RARA*)Clmd}/Gt(ROSA)26Sor⁺ Tg(Hoxb7-cre)13Amc/0 Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:157254 )

• renal hypoplasia with a 50-80% reduction in branch numbers at E14

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• 50-80% reduction in branch numbers at E14

Allelic Composition	Ctnnd1^tm1Lfr/Ctnnd1^tm1Lfr Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnd1^tm1Lfr mutation (1 available); any Ctnnd1 mutation (122 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:171425 )

N	• mice appear healthy and show no apparent defects in kidney size or morphology at 4 weeks of age • development of the ureteric bud and its derivatives (collecting ducts) appears normal

Allelic Composition	Pax2^1Neu/Pax2⁺ Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 102 * C57BL/6 * CBA * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax2^1Neu mutation (1 available); any Pax2 mutation (44 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

duplex kidney ( J:145105 )

abnormal ureter development ( J:145105 )

• at E12.25, only 12.5% of ureters have begun to separate from their corresponding mesonephric ducts relative to 70% of wild-type ureters, indicating a delay in ureter maturation

• at E14, 25% of ureters remain attached to the mesonephric duct relative to 6.25% of wild-type controls

• at E17, all ureters have independent openings into the bladder; however, their entry is at a less oblique angle relative to that in wild-type controls

• at E17, only 18% of embryos have ureters that enter the bladder at an oblique angle relative to 69% of wild-type controls

• no differences in crown-rump lengths are observed, suggesting a urinary tract specific delay

• delay in ureter maturation is not due to a altered apoptosis in the common nephric duct or surrounding tissues at E11

abnormal ureteric bud morphology ( J:145105 )

• at E10.25, some ureteric buds display irregular contours relative to wild-type controls

impaired branching involved in ureteric bud morphogenesis ( J:145105 )

• at E11.25 and E13, reduced ureteric bud branching may be observed in embryos with a duplex collecting system

ectopic ureteric bud ( J:145105 )

• at E10.25, embryos exhibit more caudally positioned ureteric buds relative to wild-type controls

Allelic Composition	Robo2^tm1.1Rilm/Robo2⁺ Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2^tm1.1Rilm mutation (0 available); any Robo2 mutation (101 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal/urinary system morphology ( J:125214 )

• mice exhibit unilateral congenital anomalies of the kidney and urinary tract with vesicouretal reflux (CAKUT-VUR)

• mice exhibit uretrovesical junctions

dilated ureter ( J:125214 )

• mice display early ureter dilation

large ureter ( J:125214 )

• mice exhibit massive and lesser megaureter

Allelic Composition	Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfia^tm1Rmg mutation (1 available); any Nfia mutation (28 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos and Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos mice have ureteral defects

renal/urinary system

abnormal kidney morphology ( J:122749 )

• dysplastic kidney

abnormal ureter development ( J:122749 )

• 33% of mutants exhibit ureteral development abnormalities, that include proximal flexion of the ureter and ureter dilation

dilated ureter ( J:122749 )

Allelic Composition	Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfia^tm1Rmg mutation (1 available); any Nfia mutation (28 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos and Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos mice have ureteral defects

renal/urinary system

abnormal ureter development ( J:122749 )

• 22% exhibit ureteral development abnormalities that include ureter dilation and partial ureteral duplication

dilated ureter ( J:122749 )

Allelic Composition	Bmp4^tm3.2Blh/Bmp4⁺ Grem1^tm1Azun/Grem1^tm1Azun Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm3.2Blh mutation (0 available); any Bmp4 mutation (21 available)
Grem1^tm1Azun mutation (1 available); any Grem1 mutation (16 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:122530 )

N	• kidneys develop and function normally unlike in Grem1^tm1Azun homozygotes

Allelic Composition	Bmp4^tm3.2Blh/Bmp4^tm3.2Blh Grem1^tm1Azun/Grem1^tm1Azun Tg(Hoxb7-EGFP)33Cos/?
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:122530 )

• mice exhibit early lethality similar to Bmp4 deficient mice

Allelic Composition	Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Gdu mutation (1 available); any Aldh1a2 mutation (36 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

impaired branching involved in ureteric bud morphogenesis ( J:157254 )

• 50% reduction in branch numbers at E18 and earlier stages

Allelic Composition	Sema3a^tm1Mcf/Sema3a^tm1Mcf Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3a^tm1Mcf mutation (0 available); any Sema3a mutation (47 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:135328 )

• most mice (95%) die within 24 hrs after birth

postnatal lethality, complete penetrance ( J:135328 )

• 100% lethality at 7 days after birth

prenatal lethality, incomplete penetrance ( J:135328 )

• mice develop slightly below Mendelian proportions until E20

renal/urinary system

abnormal branching involved in ureteric bud morphogenesis ( J:135328 )

• enhanced ureteric bud branching is observed at E11.5-E14.5

• at E12-E13, ureteric bud tips are increased by about 47-64%, then the difference gradually decreases until E15

• however, embryos do not develop multiple ureteric buds and the timing of the ureteric bud outgrowth from the Wolffian duct is normal

Allelic Composition	Tg(Hoxb7-EGFP)33Cos/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Hoxb7-EGFP)33Cos mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122788 )

• used as marker for studying ureteric bud development

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