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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Grm1)7Atai
transgene insertion 7, Atsu Aiba
MGI:3715306
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Grm1tm1Stl/Grm1tm1Stl
Pcp2tm1(tTA)23Atai/Pcp2+
Tg(tetO-Grm1)7Atai/?
involves: 129S2/SvPas * C57BL/6N MGI:3715322


Genotype
MGI:3715322
cx1
Allelic
Composition
Grm1tm1Stl/Grm1tm1Stl
Pcp2tm1(tTA)23Atai/Pcp2+
Tg(tetO-Grm1)7Atai/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm1tm1Stl mutation (0 available); any Grm1 mutation (78 available)
Pcp2tm1(tTA)23Atai mutation (0 available); any Pcp2 mutation (36 available)
Tg(tetO-Grm1)7Atai mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• ataxic gait seen in Grm1tm1Stl homozygotes is rescued by the active transgene
• following treatment with doxycycline begun at P24, mice fall off a rotating rod immediately and after several trials the average retention time is less than in wild-type mice at 41 days post treatment
• following treatment with doxycycline begun at P24, mice have abnormal gaits and steps with different degrees of severity at 37 days post treatment





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory