Phenotypes associated with this allele

• Allele Symbol: Sptan1^tm1.1Gnic
• Allele Name: targeted mutation 1.1, Gael Nicolas
• Allele ID: MGI:3714925
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptan1^tm1.1Gnic/Sptan1^tm1.1Gnic	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	MGI:3715098

Genotype
MGI:3715098

hm1

• Allelic Composition: Sptan1^tm1.1Gnic/Sptan1^tm1.1Gnic
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122549 )

• homozygotes (up to 18 months) do not show any abnormal phenotype, are indistinguishable from wild-type littermates and when mated give rise to normal, healthy litters

cellular

cellular phenotype ( J:122549 )

N • growth properties and morphology of homozygous MEFs are similar to normal MEFs

N • apoptosis occurs normally in MEFs isolated from homozygous mice; blebbing of the membrane in similar fashion as in wild-type cells