Sptan1^tm1.1Gnic
Targeted Allele Detail

Summary

• Symbol: Sptan1^tm1.1Gnic
• Name: spectrin alpha, non-erythrocytic 1; targeted mutation 1.1, Gael Nicolas
• MGI ID: MGI:3714925
• Synonyms: Spna2^R
• Gene: Sptan1 Location: Chr2:29855572-29921463 bp, + strand Genetic Position: Chr2, 20.93 cM, cytoband B
• Alliance: Sptan1^tm1.1Gnic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct was designed to insert a floxed PGK-hygro into intron 24, and a third loxP site into intron 24d. The floxed region encompassed the CCC region and was removed by crossing with mice expressing cre recombinase in the germline. The final result was a chimeric intron composed of the upper half of intron 24 and the lower part of intron 24d. (J:122549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptan1 Mutation: 130 strains or lines available

References

• Original: J:122549 Meary F, et al., A mutant alphaII-spectrin designed to resist calpain and caspase cleavage questions the functional importance of this process in vivo. J Biol Chem. 2007 May 11;282(19):14226-37
• All: 2 reference(s)