All Phenotypes Map2k1<tm1.1Chrn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k1^tm1.1Chrn
targeted mutation 1.1, Jean Charron
MGI:3714919

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k1^tm1.1Chrn/Map2k1^tm1.1Chrn	involves: 129S/SvEv * FVB/N	MGI:3714921
ht2	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159582
cn3	Map2k1^tm1Chrn/Map2k1^tm1.1Chrn Edil3^{Tg(Sox2-cre)1Amc}/?	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	MGI:3714923

Allelic Composition	Map2k1^tm1.1Chrn/Map2k1^tm1.1Chrn
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Chrn mutation (0 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:112223 )

• embryos die at E10.5 with similar phenotypes as Map2k1^{Gt(ROSABetageo)J2Chrn}

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Chrn mutation (0 available); any Map2k1 mutation (92 available)
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

skeleton

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

vision/eye

increased inner canthal distance ( J:261678 )

• width of the inner canthal distance is increased

Allelic Composition	Map2k1^tm1Chrn/Map2k1^tm1.1Chrn Edil3^{Tg(Sox2-cre)1Amc}/?
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Map2k1^tm1.1Chrn mutation (0 available); any Map2k1 mutation (92 available)
Map2k1^tm1Chrn mutation (1 available); any Map2k1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112223 )

N	• mice are fertile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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