All Phenotypes Dp(4D4Mit190-D4Mit51)1Aam MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dp(4D4Mit190-D4Mit51)1Aam
duplication, Chr 4, Alea A Mills 1
MGI:3714526

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam	involves: 129S7/SvEvBrd	MGI:3714605
cx2	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53⁺	involves: 129S7/SvEvBrd	MGI:3714608
cx3	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd	MGI:3714609
ot4	Dp(4D4Mit190-D4Mit51)1Aam/0	involves: 129S7/SvEvBrd	MGI:3714603

Allelic Composition	Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121726 )

• mice are indistinguishable from wild-type mice

Allelic Composition	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(4D4Mit190-D4Mit51)1Aam mutation (0 available); any Dp(4D4Mit190-D4Mit51)1Aam mutation (0 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:121726 )

• some mice die prior to weaning

embryo

abnormal embryo development ( J:121726 )

• defects in development are less severe than in Dp(4D4Mit190-D4Mit51)1AAM heterozygotes

growth/size/body

decreased body size ( J:121726 )

• some mice are runted

behavior/neurological

ataxia ( J:121726 )

• some mice develop ataxia

Allelic Composition	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121726 )

• mice are viable

Allelic Composition	Dp(4D4Mit190-D4Mit51)1Aam/0
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:121726 )

cellular

abnormal mitosis ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have greater a numbers of cells in G2/M (25.9% compared to 16.9% in wild-type cells)

increased neural tube apoptosis ( J:121726 )

• mice have increased apoptosis in neural tube cells

decreased cell proliferation ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have reduced proliferative potential compared to wild-type cells with greater numbers of cells in G2/M (25.9% compared to 16.9% in wild-type cells)

early cellular replicative senescence ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos exhibit earlier senescence

limbs/digits/tail

abnormal tail development ( J:121726 )

• conspicuous curling of the tail late in development

curly tail ( J:121726 )

nervous system

increased neural tube apoptosis ( J:121726 )

• mice have increased apoptosis in neural tube cells

exencephaly ( J:121726 )

vision/eye

microphthalmia ( J:121726 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23