All Phenotypes Plxnb1<tm1Rkun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plxnb1^tm1Rkun
targeted mutation 1, Rohini Kuner
MGI:3713703

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxnb1^tm1Rkun/Plxnb1^tm1Rkun	involves: FVB/N	MGI:3713709
hm2	Plxnb1^tm1Rkun/Plxnb1^tm1Rkun	Not Specified	MGI:3808769
cn3	Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Plxnb1^tm1Rkun/Plxnb1^tm1Rkun Plxnb2^tm1.1Rkun/Plxnb2^tm1.1Rkun	involves: 129P2/OlaHsd * C57BL/6	MGI:5807122

Allelic Composition	Plxnb1^tm1Rkun/Plxnb1^tm1Rkun
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1^tm1Rkun mutation (0 available); any Plxnb1 mutation (107 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:121970 )

N	• mice exhibit a normal nervous system

Allelic Composition	Plxnb1^tm1Rkun/Plxnb1^tm1Rkun
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1^tm1Rkun mutation (0 available); any Plxnb1 mutation (107 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

enlarged kidney ( J:139221 )

• at E13.5, kidneys are enlarged in length and area compared to wild-type

• however, by E15.5 kidney size is normal

abnormal metanephros morphology ( J:139221 )

• unlike wild-type kidney tissue, metanephroi fail to exhibit inhibited branching or growth in response to treatment with Sema4d in vitro

abnormal branching involved in ureteric bud morphogenesis ( J:139221 )

• at E13.5, kidneys exhibit 36% more ureteric tips than in heterozygotes; however, by E15.5 kidney morphology is normal

growth/size/body

enlarged kidney ( J:139221 )

• at E13.5, kidneys are enlarged in length and area compared to wild-type

• however, by E15.5 kidney size is normal

Allelic Composition	Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Plxnb1^tm1Rkun/Plxnb1^tm1Rkun Plxnb2^tm1.1Rkun/Plxnb2^tm1.1Rkun
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax8^{tm1.1(cre)Mbu} mutation (1 available); any Pax8 mutation (32 available)
Plxnb1^tm1Rkun mutation (0 available); any Plxnb1 mutation (107 available)
Plxnb2^tm1.1Rkun mutation (0 available); any Plxnb2 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal renal tubule epithelium morphology ( J:221423 )

• mice exhibit foci of multi-layered tubules

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