Phenotypes associated with this allele

• Allele Symbol: Rela^tm1Rsch
• Allele Name: targeted mutation 1, Roland Schmid
• Allele ID: MGI:3713697
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rela^tm1Rsch/Rela^tm1Rsch Ptf1a^tm1(cre)Hnak/?	involves: C57BL/6	MGI:3713700
cn2	Rela^tm1Rsch/Rela^tm1Rsch Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:5441219
cn3	Rela^tm1Rsch/Rela^tm1Rsch Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:5441218

Genotype
MGI:3713700

cn1

• Allelic Composition: Rela^tm1Rsch/Rela^tm1Rsch; Ptf1a^tm1(cre)Hnak/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122194 )

• 1 of 4 mice died 48 hours after induced pancreatitis

homeostasis/metabolism

abnormal interleukin level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, pancreatic levels of TNF-alpha are increased

abnormal response/metabolism to endogenous compounds ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, mice experience panreatitis with increased vascuolizaztion, morphologically apoptotic cells, ghost cells, edema, infiltrate and massive necrosis, increased pancreatic levels of TNF-alpha and IL-6 and lung inflammation characterized by alveolar fluid accumulation and progressive thickening, hyperemia, and neutrophil infiltration of interalveolar tissue

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122194 )

• 1 of 4 mice died 48 hours after induced pancreatitis

immune system

pancreas inflammation ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, mice experience panreatitis with increased vascuolizaztion, morphologically apoptotic cells, ghost cells, edema, infiltrate and massive necrosis

abnormal interleukin level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, pancreatic levels of TNF-alpha are increased

lung inflammation ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, lung inflammation is characterized by alveolar fluid accumulation and progressive thickening, hyperemia, and neutrophil infiltration of interalveolar tissue

endocrine/exocrine glands

pancreas inflammation ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, mice experience panreatitis with increased vascuolizaztion, morphologically apoptotic cells, ghost cells, edema, infiltrate and massive necrosis

respiratory system

lung inflammation ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, lung inflammation is characterized by alveolar fluid accumulation and progressive thickening, hyperemia, and neutrophil infiltration of interalveolar tissue

Genotype
MGI:5441219

cn2

• Allelic Composition: Rela^tm1Rsch/Rela^tm1Rsch; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells

immune system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells

Genotype
MGI:5441218

cn3

• Allelic Composition: Rela^tm1Rsch/Rela^tm1Rsch; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: ICR

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

immune system phenotype ( J:169863 )

N • alpha-beta Th17 cell differentiation is normal

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

decreased interleukin-17 secretion ( J:169863 )

• in TCRbeta+CD4+CD44^hi thymocytes

• in the peritoneal cavity of E. coli-infected mice

increased susceptibility to bacterial infection ( J:169863 )

• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice