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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pygo2tm1.2Ssp
targeted mutation 1.2, S Steven Potter
MGI:3712856
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tfap2atm1(cre)Moon/? 		involves: 129S1/Sv * 129X1/SvJ MGI:3711517
cn2
 		Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Tg(CMV-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713466
cn3
 		Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3711498
cn4
 		Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-cre,GFP)1Pgr/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB MGI:3711516
cn5
 		Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Pax6-cre,GFP)1Pgr/? 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:3711497
cx6
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ MGI:3711518
cx7
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3711521
cx8
 		Pygo1tm1.1Ssp/Pygo1+
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ MGI:3711520
cx9
 		Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713468


Genotype
MGI:3711517
cn1
Allelic
Composition		 Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tfap2atm1(cre)Moon/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
Tfap2atm1(cre)Moon mutation (1 available); any Tfap2a mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens induction ( J:121416 )
• at E9.5, lens induction is abnormal as indicated by reduced Pax6+ cells
small lens ( J:121416 )
• at E12.5, lens reduction is more severe than any other conditional cross but not as severe as in the Pygo2 null homozygotes




Genotype
MGI:3713466
cn2
Allelic
Composition		 Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:121918 )
• mice are born but with rare exceptions die shortly afterwards

renal/urinary system
abnormal kidney morphology ( J:121918 )
• at high penetrance
abnormal ureter development ( J:121918 )
• at E18.5, mesenchyme surrounding the ureteric buds is thickened 30% and ureteric tips are dilated and misshaped
• however, nephrogenesis is normal

vision/eye
aphakia ( J:121918 )
• at high penetrance

growth/size/body
cleft palate ( J:121918 )
• at low penetrance
decreased fetal size ( J:121918 )
• at high penetrance
fetal growth retardation ( J:121918 )
• at high penetrance

nervous system
exencephaly ( J:121918 )
• at low penetrance

craniofacial
cleft palate ( J:121918 )
• at low penetrance

digestive/alimentary system
cleft palate ( J:121918 )
• at low penetrance




Genotype
MGI:3711498
cn3
Allelic
Composition		 Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• at E12.5, lens size is reduced comparable to Pygo2tm1Lan/Pygo2tm1.1Lan mice




Genotype
MGI:3711516
cn4
Allelic
Composition		 Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-cre,GFP)1Pgr/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• at E12.5, lens reduction is more severe that in either single cre cross but not as severe as in the Pygo2 null homozygotes




Genotype
MGI:3711497
cn5
Allelic
Composition		 Pygo2tm1.1Ssp/Pygo2tm1.2Ssp
Tg(Pax6-cre,GFP)1Pgr/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• at E12.5, lenses were small compared to normal but not as severe as in Pygo2 null homozygotes




Genotype
MGI:3711518
cx6
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes




Genotype
MGI:3711521
cx7
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:121416 )
N
• lens sizes are normal




Genotype
MGI:3711520
cx8
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1+
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
small lens ( J:121416 )
• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes




Genotype
MGI:3713468
cx9
Allelic
Composition		 Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small size, eye defects and exencephaly in Pygo1tm1.1Ssp/Pygo1tm1.1Ssp Pygo2tm1.2Ssp/Pygo2tm1.2Ssp mice at E18.5

mortality/aging
neonatal lethality, incomplete penetrance ( J:121918 )
• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

renal/urinary system
abnormal ureter development ( J:121918 )
• ureteric bud numbers are decreased 25% in mice with kidney defects

vision/eye
aphakia ( J:121918 )
• absent or rudimentary lens
abnormal retina morphology ( J:121918 )
• retinas are absent or rudimentary and the pigmented retina is folded
retina fold ( J:121918 )
• the pigmented retina is folded

growth/size/body
decreased fetal size ( J:121918 )
fetal growth retardation ( J:121918 )
• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity

nervous system
exencephaly ( J:121918 )
• seen in a small percentage of fetuses




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory