Phenotypes associated with this allele

• Allele Symbol: Cxcl9^tm1Jmf
• Allele Name: targeted mutation 1, Joshua M Farber
• Allele ID: MGI:3712351
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl9^tm1Jmf/Cxcl9^tm1Jmf	B6.129S4-Cxcl9^tm1Jmf	MGI:3712765
hm2	Cxcl9^tm1Jmf/Cxcl9^tm1Jmf	either: B6.129S4-Cxcl9^tm1Jmf or (involves: 129S4/SvJae * C57BL/6)	MGI:3712736

Genotype
MGI:3712765

hm1

• Allelic Composition: Cxcl9^tm1Jmf/Cxcl9^tm1Jmf
• Genetic Background: B6.129S4-Cxcl9^tm1Jmf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:120743 )

• mice have reduced levels of CCL3, CCL5, CXCL1 and CXCL10 expression in the cornea of mice compared to Cxcl10-null or wild-type mice; levels of Il-10, Il-6, and Tnfa are undetectable or much lower in Cxcl9-deficient corneas

decreased inflammatory response ( J:120743 )

• reduction in recruitment of CD4+ T cells is detected in central and peripheral cornea compared to wild-type

• CD8+ T cell infilitration is comparable to wild-type mice

Genotype
MGI:3712736

hm2

• Allelic Composition: Cxcl9^tm1Jmf/Cxcl9^tm1Jmf
• Genetic Background: either: B6.129S4-Cxcl9^tm1Jmf or (involves: 129S4/SvJae * C57BL/6)

mortality/aging

mortality/aging ( J:121818 )

N • Cxcl9-deficient mice show no differences in mortality upon primary infection or after lethal challenge of mice surviving primary infection with L. monocytogenes, F. tularensis LVS, Toxoplasma gondii, or after primary infection with S. typhimurium, vaccinia virus, ectromelia virus, hsv type I, Histolplasma capsulatum , Cryptococcus neoformans, or Mycobacterium avium

immune system

immune system phenotype ( J:121818 )

N • mice show no difference from wild-type in peripheral leukocyte and differential counts or in constituent cell populations in thymus (double negative, double positive, and single positive thymocytes), spleen (CD4+ and CD8+ T cells, B cells, macrophages, and NK cell populations), or peritoneum (B1-B cells)

N • bacterial clearance after F. tularensis infection is comparable to wild-type, with no live organisms found in spleens 3 weeks post-infection

N • no reproducible differences are seen in antibody titers after immunization with T cell-dependent or T-independent antigens

N • no significant or reproducible differences were found compared to wild-type littermates with respect to liver inflammation after infection with L. monocytogenes or T. gondii, number of brain cysts with T. gondii infection, differences in peritoneal exudates with T. gondii infection, splenocytes after M. avium infection, or footpad swelling with inoculation with ectromelia virus

decreased immunoglobulin level ( J:121818 )

• mice produce lower titers of antibodies in response to primary infection with Francisella tularensis LVS

decreased IgG level ( J:121818 )

• titers of anti-Francisella IgG and the major isotype against this organism IgG_2a/c are reduced in null mice using F2 mice or those backcrossed more to C57BL/6

hematopoietic system

decreased immunoglobulin level ( J:121818 )

• mice produce lower titers of antibodies in response to primary infection with Francisella tularensis LVS

decreased IgG level ( J:121818 )

• titers of anti-Francisella IgG and the major isotype against this organism IgG_2a/c are reduced in null mice using F2 mice or those backcrossed more to C57BL/6