Cxcl9^tm1Jmf
Targeted Allele Detail

Summary

• Symbol: Cxcl9^tm1Jmf
• Name: C-X-C motif chemokine ligand 9; targeted mutation 1, Joshua M Farber
• MGI ID: MGI:3712351
• Synonyms: Cxcl9^-, Mig^-
• Gene: Cxcl9 Location: Chr5:92469206-92475938 bp, - strand Genetic Position: Chr5, 46.51 cM
• Alliance: Cxcl9^tm1Jmf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121818
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin resistance gene resulted in the deletion of 1458 bp of the locus, including 104 bp of exon 2 and 1354 bp of intron 2. The predicted mRNA consists of the signal peptide followed by 7 amino-terminal amino acids and a stop codon. Western blot confirmed absence of protein in mutant liver microsomes. (J:121818)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcl9 Mutation: 12 strains or lines available

References

• Original: J:121818 Park MK, et al., The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo. J Immunol. 2002 Aug 1;169(3):1433-43
• All: 21 reference(s)