Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
UmodUrehd1 mutation
(0 available);
any
Umod mutation
(4 available)
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growth/size/body
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• from 5 weeks of age onwards
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homeostasis/metabolism
renal/urinary system
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• at 20-22 months of age, more severe than heterozygous mutants
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• at 20-22 months of age, more severe than heterozygous mutants
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• elevated plasma cystatin C levels indicate decreased glomerular filtration rate at 4 months of age
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cellular
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• at 20-22 months of age, more severe than heterozygous mutants
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
UmodUrehd1 mutation
(0 available);
any
Umod mutation
(4 available)
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growth/size/body
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• phenotypic mutant mice eat more, but gain less weight than controls
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adipose tissue
homeostasis/metabolism
renal/urinary system
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• urinary creatinine and urea/creatinine ratios are decreased in 24 hour urine output of phenotypic mutants of both sexes
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• urine potassium/creatinine ratio is increased in 24-hour and spot urine samples of phenotypic mutants
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• urine sodium/creatinine and chloride/creatinine ratios tend to be decreased in 24-hour urine and spot urine samples of phenotypic mutants
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• rate is decreased in phenotypic mutants of both sexes
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• observed in phenotypic mutants
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behavior/neurological
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• phenotypic mutants show increased water intake in metabolism cages
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• phenotypic mutant mice show increased food intake
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Allelic Composition |
UmodUrehd1/Umod+
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Genetic Background |
involves: C3HeB/FeJ |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
UmodUrehd1 mutation
(0 available);
any
Umod mutation
(4 available)
|
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growth/size/body
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• starting from 4 weeks of age in males and 7 weeks of age in females
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• in some mice at 20 months of age
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adipose tissue
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• 69-81% decrease in fat mass at 9 months of age
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cellular
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• strongly dilated in the perinuclear intracytoplasmic compartment of thick ascending limb of Henle's loop cells
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skeleton
homeostasis/metabolism
renal/urinary system
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• in some mice at 20 months of age
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• increase in fractional excretion at 9 months of age
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• increase in 24 h excretion and fractional excretion at 9 months of age
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• increase fractional excretion at 9 months of age
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• increase in 24 h excretion and fractional excretion at 9 months of age
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• increase in 24 h excretion and fractional excretion at 9 months of age
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• with or without deprivation of drinking water
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• daily urea excretion is increased but fractional excretion and urine-to-plasma concentration ratio are decreased
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• decrease in 24 h excretion and fractional excretion at 9 months of age
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• in some mice at 20 months of age
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• intracytoplasmic inclusions in cells at 4 months of age
• strongly dilated in the perinuclear intracytoplasmic compartment of thick ascending limb of Henle's loop cells
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• in 9 month old mice with or without deprivation of drinking water
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