mortality/aging
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• all mice exhibit perinatal lethality
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vision/eye
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• at E15.5, cornea does not form properly and only a single surface epithelium is found where the cornea should be
• at E15.5, hyaloid cavity is absent
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• lenses are poorly differentiated
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• cuboidal cells surround the lens that persist at E18.5
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• at all stages examined mice have smaller or no lens
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• at all stages examined mice have smaller or no lens
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• between E12.5 and term, 25% of mice have small eyes that are often distinct from brain abnormalities
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• at E15.5, eyelids fail to form and close properly
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digestive/alimentary system
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• at E18.5, greater than 90% of mice have an approximately 10% to 15% reduction in the length of the small intestine coinciding with decreased body size
• however, intervillous regions, cell proliferation in the intestine and histological morphology are normal
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craniofacial
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• between E12.5 and term, 14% of 63 mice exhibit exencephaly or a domed head
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nervous system
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• between E12.5 and term, 14% of 63 mice have enlarged brains
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• between E12.5 and term, 14% of 63 mice exhibit exencephaly or a domed head
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respiratory system
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• at E18.5, lungs contain airways that terminate in large, smooth-walled cylindrical structures
• at E18.5, thinning of the interstitial tissue is defective
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growth/size/body
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• mice are born slightly runted with about a 10% reduction in length
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• mice are born with a 15% to 20% reduction in weight
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skeleton
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• between E12.5 and term, 14% of 63 mice exhibit exencephaly or a domed head
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integument
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• mild
• most mice have normal or lightly elongated follicles
• one newborn had arrested hair follicle development with a 30% decrease in hair follicle density
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Analysis Tools
