Pygo2^tm1.2Xdai
Targeted Allele Detail

Summary

• Symbol: Pygo2^tm1.2Xdai
• Name: pygopus 2; targeted mutation 1.2, Xing Dai
• MGI ID: MGI:3711739
• Synonyms: mpygo2^-
• Gene: Pygo2 Location: Chr3:89337521-89342435 bp, + strand Genetic Position: Chr3, 39.12 cM
• Alliance: Pygo2^tm1.2Xdai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121776
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3, which encodes amino acids 52-405 of the protein, including a conserved PHD finger domain, was removed via cre mediated recombination. Absence of transcript was confirmed by Northern blot and absence of protein was confirmed by Western blot. (J:121776)

Expression

In Mice Carrying this Mutation:	40 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pygo2 Mutation: 24 strains or lines available

References

• Original: J:121776 Li B, et al., Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May;45(5):318-25
• All: 6 reference(s)