All Phenotypes Spen<tm2.1Hon> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spen^tm2.1Hon
targeted mutation 2.1, Tasuku Honjo
MGI:3710413

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Spen^tm2.1Hon/Spen^tm2.1Hon	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3710553
cn2	Cd19^tm1(cre)Cgn/Cd19⁺ Rbpj^tm1Hon/Rbpj^tm1Hon Spen^tm2.1Hon/Spen^tm2.1Hon	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3710554
cn3	Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Nes-cre)1Kag/?	involves: C57BL/6 * CBA	MGI:3710557
cn4	Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Camk2a-cre)10Kmik/?	involves: C57BL/6 * CBA	MGI:3710558

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Spen^tm2.1Hon/Spen^tm2.1Hon
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Spen^tm2.1Hon mutation (3 available); any Spen mutation (140 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased follicular B cell number ( J:121523 )

• decreased numbers of follicular B cells in spleen

increased marginal zone B cell number ( J:121523 )

• increased numbers of marginal zone B cells in spleen

hematopoietic system

decreased follicular B cell number ( J:121523 )

• decreased numbers of follicular B cells in spleen

increased marginal zone B cell number ( J:121523 )

• increased numbers of marginal zone B cells in spleen

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Rbpj^tm1Hon/Rbpj^tm1Hon Spen^tm2.1Hon/Spen^tm2.1Hon
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (193 available)
Spen^tm2.1Hon mutation (3 available); any Spen mutation (140 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased marginal zone B cell number ( J:121523 )

• severely decreased numbers of marginal zone B cells in spleen

increased follicular B cell number ( J:121523 )

• increased numbers of follicular B cells in spleen

hematopoietic system

decreased marginal zone B cell number ( J:121523 )

• severely decreased numbers of marginal zone B cells in spleen

increased follicular B cell number ( J:121523 )

• increased numbers of follicular B cells in spleen

Allelic Composition	Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Nes-cre)1Kag/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spen^tm2.1Hon mutation (3 available); any Spen mutation (140 available)
Tg(Nes-cre)1Kag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:121523 )

• increased mortality before 10 weeks of age

growth/size/body

postnatal growth retardation ( J:121523 )

• although normal at birth, mice are growth retarded at 3 weeks of age

nervous system

decreased brain weight ( J:121523 )

abnormal telencephalon morphology ( J:121523 )

enlarged lateral ventricles ( J:121523 )

small hippocampus ( J:121523 )

• reduced in size

thin cerebral cortex ( J:121523 )

• severe reductions in the thickness of the cerebral cortex

Allelic Composition	Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Camk2a-cre)10Kmik/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spen^tm2.1Hon mutation (3 available); any Spen mutation (140 available)
Tg(Camk2a-cre)10Kmik mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain size ( J:121523 )

• brain hypoplasia by 8 weeks of age

behavior/neurological

abnormal learning/memory/conditioning ( J:121523 )

• reduced freezing response to foot shock during training

abnormal contextual conditioning behavior ( J:121523 )

• reduced freezing response

abnormal cued conditioning behavior ( J:121523 )

• reduced freezing response

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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