Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88tm1.1Bky mutation
(0 available);
any
Ift88 mutation
(48 available)
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mortality/aging
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• embryos are arrested at stage E9.5
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embryo
cardiovascular system
homeostasis/metabolism
cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88tm1.1Bky mutation
(0 available);
any
Ift88 mutation
(48 available)
Ift88tm1Rpw mutation
(0 available);
any
Ift88 mutation
(48 available)
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nervous system
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• at E11.5, the neural tube is misaligned
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• at E11.5, the neural tube is not closed
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cardiovascular system
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• at E11.5, the cardiac sac balloons
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embryo
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• at E11.5, the neural tube is misaligned
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• at E11.5, the neural tube is not closed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88cbbs mutation
(0 available);
any
Ift88 mutation
(48 available)
Ift88tm1.1Bky mutation
(0 available);
any
Ift88 mutation
(48 available)
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nervous system
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• at E11.5, the telencephalon is shortened along its rostral-caudal axis compared to in wild-type mice
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• at E11.5, the dorsal telencephalic midline is barely invaginated, the cortical ventricular zone is reduced to a thin strip, and the medial and lateral ganglionic eminences are reduced in size
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cardiovascular system
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• 3 of 7 mice exhibit a rightward-looping heart tube
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vision/eye
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• bilaterally in all mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88tm1.1Bky mutation
(0 available);
any
Ift88 mutation
(48 available)
Ift88tm1Bky mutation
(1 available);
any
Ift88 mutation
(48 available)
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limbs/digits/tail
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• at E11.5, the ventral (but not the dorsal) ectoderm of the limb bud is nearly devoid of cilia
• however, normal limbs form
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embryo
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• at E11.5, the ventral (but not the dorsal) ectoderm of the limb bud is nearly devoid of cilia
• however, normal limbs form
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88tm1.1Bky mutation
(0 available);
any
Ift88 mutation
(48 available)
Ift88tm1Bky mutation
(1 available);
any
Ift88 mutation
(48 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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skeleton
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• at E18.5, mice display varying severities of endochondral bone defects in all long bones with dramatic reduction in overall length
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• mice lack expression of an osteoblast-specific marker (alkaline phosphates) in the perichondrium
• cells adjacent to the perichondrium resemble chondrocytes rather than osteoblast
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• at E18.5, proliferating chondrocytes in the growth region of the tibia are round and flat
• at E18.5, only small cilia are occasionally observed on chondrocytes of the developing tibia
• at E18.5, ectopic chondrocytes are seen in the perichondrium
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• at E18.5, perichondrial cells are disorganized, do not adopt the characteristic flattened morphology and are not evenly distributed along the bone
• at E18.5, bone collar formation is absent in the tibia
• at E18.5, some cells in the perichondrium appear to be differentiating into chondrocytes rather than into osteoblasts
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• at E18.5, bone vascularization is delayed and hypertrophic cells persist
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• at E18.5, the growth region of the tibia contains only a small disorganized area of round and flat proliferating chondrocytes
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• at E18.5, the growth region of the tibia contains only a small disorganized area of round and flat proliferating chondrocytes
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• only some regions of the tibia contain mineralized bone
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limbs/digits/tail
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• at E11.5, very few cells with cilia are present in the limb mesenchyme
• however, cilia of the overlying ectoderm is normal
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• at E18.5, mice have 8 or more non-patterned digits on their forelimbs while each hindlimb has a single extra preaxial digit (typically a duplication of digit 1)
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• at E13.5 and P11, all four limbs are shortened in the proximodistal axis
• however, limb patterning is normal
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growth/size/body
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• mice are smaller postnatally
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embryo
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• at E11.5, very few cells with cilia are present in the limb mesenchyme
• however, cilia of the overlying ectoderm is normal
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Analysis Tools