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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otofpga
pachanga
MGI:3708344
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otofpga/Otofpga involves: C57BL/6J MGI:3709036


Genotype
MGI:3709036
hm1
Allelic
Composition		 Otofpga/Otofpga
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otofpga mutation (0 available); any Otof mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased startle reflex ( J:119820 )
• low auditory startle response

hearing/vestibular/ear
abnormal cochlear hair cell stereociliary bundle morphology ( J:119820 )
• hair bundles appeared slightly distorted under light microscopy
• hair bundles are split at times
increased or absent threshold for auditory brainstem response ( J:119820 )
• auditory threshold of more than 90 dB, indicating that lines are severely hearing impaired in 3-weeks old and 2 month old animals

nervous system
abnormal cochlear hair cell stereociliary bundle morphology ( J:119820 )
• hair bundles appeared slightly distorted under light microscopy
• hair bundles are split at times




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory