Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1.1Cgh mutation
(0 available);
any
Sphk1 mutation
(30 available)
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cardiovascular system
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• decrease in in vitro cardiomyocyte viability when exposed to hypoxia and glucose-deprivation for 4 hrs
• however, viability is no different from wild-type cardiomyocytes under normoxic culture conditions and pre-treatment with1uM of shingosine-1-phosphate improves viability
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immune system
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
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• in the spleen and lymph
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• in bone marrow and slightly in the lymph nodes
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• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal
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• undetectable levels of sphingosine-1-phosphate (S1P) in the plasma and lymph
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hematopoietic system
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• decrease in the number of mature B cells in the bone marrow
• however, immature cell numbers are similar to controls
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• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
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• in the spleen and lymph
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• in bone marrow and slightly in the lymph nodes
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• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal
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endocrine/exocrine glands
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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cardiovascular system
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• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes
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• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes and transfusion with wild-type platelets reduces vascular leakage of FITC-dextran
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