Phenotypes associated with this allele

• Allele Symbol: Cd40^tm1Arah
• Allele Name: targeted mutation 1, Amin Rahemtulla
• Allele ID: MGI:3707600
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd40^tm1Arah/Cd40^tm1Arah	B6.129S1-Cd40^tm1Arah	MGI:3709480

Genotype
MGI:3709480

hm1

• Allelic Composition: Cd40^tm1Arah/Cd40^tm1Arah
• Genetic Background: B6.129S1-Cd40^tm1Arah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent spleen germinal center ( J:120512 )

• germinal centers do not form when stimulated with a thymus-dependent antigen

abnormal immunoglobulin level ( J:120512 )

decreased IgE level ( J:120512 )

• IgE levels are undetectable under normal conditions

increased IgG3 level ( J:120512 )

• IgG3 levels are elevated under normal conditions

decreased IgG level ( J:120512 )

• no IgG is detected in an alloantibody response to MHC class I molecule D^d

decreased IgG1 level ( J:120512 )

• IgG1 levels are reduced

decreased IgG2b level ( J:120512 )

• IgG2b levels are reduced and IgG2b levels are low under normal conditions

decreased IgM level ( J:120512 )

• little IgM is detected in an alloantibody response to MHC class I molecule D^d

increased IgM level ( J:120512 )

• IgM levels are increased under normal conditions

abnormal response to transplant ( J:120512 )

• transplant arteriosclerosis is reduced when IL4 is inhibited in CD8+ T cell depleted mice to a greater degree than in control mice under the same treatment conditions

• however, intimal proliferation of transplant arteriosclerosis is similar to controls mice even when Cd8+ T cells are depleted

• decrease in CD4+ and CD8+ T cell and macrophage (CD11b+) infiltration of aortic allografts with an increase in eosinophil graft infiltration

• however, neutralization of IL4 reduces eosinophil proliferation and infiltration of aortic allografts

hematopoietic system

absent spleen germinal center ( J:120512 )

• germinal centers do not form when stimulated with a thymus-dependent antigen

abnormal immunoglobulin level ( J:120512 )

decreased IgE level ( J:120512 )

• IgE levels are undetectable under normal conditions

increased IgG3 level ( J:120512 )

• IgG3 levels are elevated under normal conditions

decreased IgG level ( J:120512 )

• no IgG is detected in an alloantibody response to MHC class I molecule D^d

decreased IgG1 level ( J:120512 )

• IgG1 levels are reduced

decreased IgG2b level ( J:120512 )

• IgG2b levels are reduced and IgG2b levels are low under normal conditions

decreased IgM level ( J:120512 )

• little IgM is detected in an alloantibody response to MHC class I molecule D^d

increased IgM level ( J:120512 )

• IgM levels are increased under normal conditions