All Phenotypes Mesp2<tm10Ysa> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mesp2^tm10Ysa
targeted mutation 10, Yumiko Saga
MGI:3707537

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm10Ysa/Mesp2^tm10Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709542
ht2	Mesp2^tm10Ysa/Mesp2^tm11Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709551
cx3	Mesp2^tm1Ysa/Mesp2^tm10Ysa Gt(ROSA)26Sor/?	involves: 129 * C57BL/6 * CBA	MGI:3709491
cx4	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm10Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709550

Allelic Composition	Mesp2^tm10Ysa/Mesp2^tm10Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:119678 )

abnormal vertebrae morphology ( J:119678 )

abnormal thoracic vertebrae morphology ( J:119678 )

abnormal cervical vertebrae morphology ( J:119678 )

abnormal vertebrae development ( J:119678 )

• at E17.5, mice have skeletal defects in the anterior region of the vertebra along the anterior posterior axis

• defects are less severe than in Mesp2^tm11Ysa homozygotes

Allelic Composition	Mesp2^tm10Ysa/Mesp2^tm11Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
Mesp2^tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:119678 )

• vertebral defects extend to the lumbar level in the most posterior vertebra region

fusion of vertebral arches ( J:119678 )

Allelic Composition	Mesp2^tm1Ysa/Mesp2^tm10Ysa Gt(ROSA)26Sor/?
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor mutation (16 available); any Gt(ROSA)26Sor mutation (944 available)
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
Mesp2^tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure of somite differentiation ( J:120635 )

• epithelial somites do not form and the entire somatic mesoderm is caudalized

• however, dermamyotome and sclerotome differentiation is unaffected

Allelic Composition	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm10Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2^tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp1/Mesp2^tm1Ysa mutation (2 available); any Mesp1 mutation (17 available)
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body length ( J:119678 )

• shortening of the trunk region

skeleton

abnormal vertebrae morphology ( J:119678 )

• severe truncation of the vertebra

fusion of vertebral arches ( J:119678 )

• severe fusion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23