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Gene trapped Allele Detail
Symbol: Gt(ROSA)26Sor
Name: gene trap ROSA 26, Philippe Soriano
MGI ID: MGI:1890203
Synonyms: gtrosa26, R26R3, R26tg, ROSA26, Rosa26lacZ, ROSA26-lacZ, TgR(ROSA26)26Sor
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sor page
Mutant Cell Line:  FHCRC-GT-ROSA26
Germline Transmission:  Earliest citation of germline transmission: J:79478
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Gene trapped (Not Applicable)
Mutation:    Insertion of gene trap vector     Vector: ROSABetageo
Mutation detailsRandom insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. (J:39814, J:79478)
Inheritance:    Not Specified
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 16 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  795 strains or lines available
ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells.
Original:  J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
All:  105 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory