All Phenotypes Tg(CD2-TcraF5,CD2-TcrbF5)1Kio MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CD2-TcraF5,CD2-TcrbF5)1Kio
transgene insertion 1, Dimitris Kioussis
MGI:3706698

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd8a^tm1Asin/Cd8a^tm1Asin Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N	MGI:3760628
cx2	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(Cd4-BCL2G101AD102A*D103A)AWnt/0	involves: C57BL/6 * C57BL/10	MGI:5661486
cx3	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(LCKprBCL2)36Sjk/0	involves: C57BL/6 * C57BL/10	MGI:5661487
tg4	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0	involves: BALB/c * C57BL/10	MGI:3706793
tg5	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0	involves: C57BL/10	MGI:3706791
tg6	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0	involves: C57BL/10 * CBA/Ca	MGI:3706792
tg7	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N	MGI:3760626

Allelic Composition	Cd8a^tm1Asin/Cd8a^tm1Asin Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8a^tm1Asin mutation (0 available); any Cd8a mutation (36 available)
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles

hematopoietic system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(Cd4-BCL2G101AD102A*D103A)AWnt/0
Genetic Background	involves: C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis indicating impaired clonal deletion

increased T cell number ( J:217939 )

enlarged lymph nodes ( J:217939 )

• lymphoid organs are mildly enlarged

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis indicating impaired clonal deletion

increased T cell number ( J:217939 )

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0 Tg(LCKprBCL2)36Sjk/0
Genetic Background	involves: C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio mutation (0 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
Genetic Background	involves: BALB/c * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- thymocytes is reduced from ~20% on a C57BL/10 background to ~4% on this background (H-2^b x H-2^d)

immune system

decreased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- thymocytes is reduced from ~20% on a C57BL/10 background to ~4% on this background (H-2^b x H-2^d)

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
Genetic Background	involves: C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113713 )

• ratio of CD8+/CD4+ T cells increases from 0.5 in lymph nodes of control mice to 8 in transgenic mice

• positive selection of thymocytes bearing the transgenic TCR occurs, and leads to a bias towards CD8+ phenotype in mice of the H-2^b haplotype

increased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- cells increases from 2% in controls to 8-30% in transgenic thymus, along with a decrease in CD4+8- cells to 2% from 9% in controls

• in the lymph nodes, 70% of cells in transgenic mice are CD8+4- compared to 25% in controls

hematopoietic system

abnormal positive T cell selection ( J:113713 )

• positive selection of thymocytes bearing the transgenic TCR occurs, and leads to a bias towards CD8+ phenotype in mice of the H-2^b haplotype

• ratio of CD8+/CD4+ T cells increases from 0.5 in lymph nodes of control mice to 8 in transgenic mice

increased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- cells increases from 2% in controls to 8-30% in transgenic thymus, along with a decrease in CD4+8- cells to 2% from 9% in controls

• in the lymph nodes, 70% of cells in transgenic mice are CD8+4- compared to 25% in controls

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
Genetic Background	involves: C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- thymocytes is reduced from ~20% on a C57BL/10 background to ~4% on this background (H-2^b x H-2^d)

immune system

decreased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- thymocytes is reduced from ~20% on a C57BL/10 background to ~4% on this background (H-2^b x H-2^d)

Allelic Composition	Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• CD8-positive T cells make up about 69% of lymph node cells

immune system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• CD8-positive T cells make up about 69% of lymph node cells

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