Analysis Tools|
Allele Symbol Allele Name Allele ID |
Man1a2tm1.1Ahe targeted mutation 1.1, Annette Herscovics MGI:3703789 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neonates die within several hours of birth
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• within several hours of birth, display signs of respiratory distress
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Thick interalveolar septae and alveolar hemorrhaging in E18.5 Man1a2tm1.1Ahe/Man1a2tm1.1Ahe lungs
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• neonates die within several hours of birth
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• neonates exhibit alveolar hemorrhaging
• however, pulmonary capillary and blood vessel networks are normal
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• lung development is delayed, with E18.5 and neonatal lungs at the canalicular stage of development instead of at the saccular stage, as in wild-type
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• decrease in alveolar air space at E18.5
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• small isolated atelectactic regions are occasionally seen in the lungs, however all lungs inflate sufficiently to briefly sustain life (4-10 hours)
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• thickening of alveolar septae is seen at E18.5
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• within several hours of birth, progressively display signs of respiratory distress
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• neonates exhibit alveolar hemorrhaging
• however, pulmonary capillary and blood vessel networks are normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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