Phenotypes associated with this allele

• Allele Symbol: Tg(APOC3)3707Bres
• Allele Name: transgene insertion 3707, Jan L Breslow
• Allele ID: MGI:3703618
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOC3)3707Bres/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:4367083
cx2	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOC3)3707Bres/? Tg(Mt1-CETP)#Tall/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:4941579
tg3	Tg(APOC3)3707Bres/0	involves: C57BL/6J * CBA/J	MGI:3710973

Genotype
MGI:4367083

cx1

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APOC3)3707Bres/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:37861 )

• DL-LDL levels increased about 2 fold over the 32mg/dl level found in mice carrying only the transgene

• 3-4 fold increase in IDL-LDL on a Western diet over the 86mg/dl level found in mice carrying only the transgene but also on a Western diet

increased circulating VLDL cholesterol level ( J:37861 )

• increased 10 fold over the level of 50mg/dl or less found in mice carrying only the transgene

• more pronounced increase when fed a Western diet

cardiovascular system

atherosclerotic lesions ( J:37861 )

• lesions at the base of the aorta are 2-3 times the size of lesions in mice lacking the transgene but homozygous for Ldlr deficiency

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial combined hyperlipidemia		DOID:13809	OMIM:144250	J:37861

Genotype
MGI:4941579

cx2

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APOC3)3707Bres/?; Tg(Mt1-CETP)#Tall/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:37861 )

• lowered by 79% on a normal diet

• lowered by 36% on a Western diet

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating LDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating VLDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating triglyceride level ( J:37861 )

• triglycerides shifted from VLDL to IDL-LDL and HDL

Genotype
MGI:3710973

tg3

• Allelic Composition: Tg(APOC3)3707Bres/0
• Genetic Background: involves: C57BL/6J * CBA/J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:119638 )

N • the mean fasting plasma glucose concentration is essentially identical in transgenic mice and littermate controls

N • the mean fasting plasma insulin concentration is essentially identical in transgenic mice and littermate controls

N • insulin-mediated glucose uptake does not differ between transgenic mice and littermate controls, based on their attaining similar steady-state plasma glucose (SSPG) and steady-state plasma insulin (SSPI) levels following co-infusion of glucose (14.5 mg/min per g body weight) and insulin (0.2 ng/min per gram body weight)

increased circulating cholesterol level ( J:119638 )

• the mean fasting cholesterol is significantly higher in 7-8-month old transgenic mice (3.5 +/- 0.2 mmol/l) than in littermate controls (2.4 +/- mmol/l) (P<0.001)

increased circulating triglyceride level ( J:119638 )

• the mean fasting plasma triglyceride concentration is considerably higher in 7-8-month old transgenic mice (11.8 +/- 0.2 mmol/l) than in littermate controls (1.1 +/- 0.1 mmol/l) (P<0.001)

adipose tissue

adipose tissue phenotype ( J:119638 )

N • epididymal fat pad adipocytes isolated from transgenic and control mice exhibit similar glucose transport rates at a maximal insulin concentration (Vmax)

N • the insulin concentration inducing half-maximal glucose transport rate (ED50) is similar in epididymal fat pad adipocytes isolated from transgenic and control mice

N • isoproterenol-induced lipolysis, measured by glycerol release, is essentially identical in transgenic and control epididymal fat pad adipocytes over a dose range of 10^-9-10^-6

N • insulin inhibition of isoproterenol-induced lipolysis, as measured by glycerol release, is essentially identical in transgenic and control epididymal fat pad adipocytes