Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation
(3 available);
any
Fcer1a mutation
(21 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation
(0 available)
|
|
|
cardiovascular system
|
|
• slight change in vascular permeability is observed in anaphylaxis model
|
immune system
|
|
• mice show a drop in rectal temperature similar to wild-type controls in the model of anaphylaxis; anaphylaxis is restored compared to Fcer1a-null mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation
(1 available);
any
Ms4a2 mutation
(12 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation
(0 available)
|
|
|
immune system
|
|
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
|
|
|
• mice show a weaker response (temperature drop) in a model of anaphlaxis (injections of IgE every 12 hours for 36 hours, then antigenic challenge)
|
|
|
• Il-6 production in stimulated BMMCs is reduced compared to Ms4a2-heterozygous transgenic mice
|
hematopoietic system
|
|
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
immune system
|
N |
• epidermal Langerhans cells are found at similar levels in mutants and controls; expression levels and patterns of Fcer1a are similar also
|
Analysis Tools