Analysis Tools
mortality/aging
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• with conditional deletion in the epiblast, no homozygous embryos are detected at E10.5
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Allele Symbol Allele Name Allele ID |
Lamtor2tm1.1Lah targeted mutation 1.1, Lukas A Huber MGI:3701993 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• with conditional deletion in the epiblast, no homozygous embryos are detected at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are born alive but die shortly after birth
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• defect is fatal leading to rapid dehydration and neonatal death
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• proliferation in epidermis is reduced with mitotic cells reduced to 50% of total; BrdU-labeled cells in epidermis are reduced by 54%, with labeled cells residing in the basal layer
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• defect is fatal leading to rapid dehydration and neonatal death
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• epidermis consists of 4 or less layers with nucleated cells frequently found in the uppermost cell layer at E18.5
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• cornified layer is not well defined at E18.5
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• granular layer is not well defined at E18.5
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• thinner than in heterozygotes
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• mutant skin is erythemic at E18.5
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• at E18.5, mutant skin appears moist compared to heterozygous littermates
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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