All Phenotypes Fadd<tm1Mpa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fadd^tm1Mpa
targeted mutation 1, Manolis Pasparakis
MGI:3700154

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Cyld^tm1.1Mpa Tg(Vil1-cre)997Gum	MGI:5293400
cn2	Fadd^tm1Mpa/Fadd^tm1Mpa Myd88^tm1Aki/Myd88^tm1Aki Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Myd88^tm1Aki Tg(Vil1-cre)997Gum	MGI:5293405
cn3	Fadd^tm1Mpa/Fadd^tm1Mpa Ripk3^tm1Vmd/Ripk3^tm1Vmd Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Ripk3^tm1Vmd Tg(Vil1-cre)997Gum	MGI:5293399
cn4	Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Tg(Vil1-cre)997Gum	MGI:5293398
cn5	Fadd^tm1Mpa/Fadd^tm1Mpa Tnf^tm1Gkl/Tnf^tm1Gkl Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Tnf^tm1Gkl Tg(Vil1-cre)997Gum	MGI:5293404
cn6	Fadd^tm1Mpa/Fadd^tm1Mpa Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:7256619
cn7	Fadd^tm1Mpa/Fadd^tm1Mpa Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N	MGI:3700376
cn8	Fadd^tm1Mpa/Fadd^tm1Mpa Mog^tm1(cre)Gkl/Mog⁺	involves: C57BL/6 * SJL	MGI:4880724

Allelic Composition	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Cyld^tm1.1Mpa Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyld^tm1.1Mpa mutation (0 available); any Cyld mutation (43 available)
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:175865 )

N	• mice do not develop colitis

decreased Paneth cell number ( J:175865 )

• reduced numbers

cecum inflammation ( J:175865 )

endocrine/exocrine glands

decreased Paneth cell number ( J:175865 )

• reduced numbers

immune system

cecum inflammation ( J:175865 )

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Myd88^tm1Aki/Myd88^tm1Aki Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Myd88^tm1Aki Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Myd88^tm1Aki mutation (9 available); any Myd88 mutation (50 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:175865 )

N	• mice do not develop colitis

decreased Paneth cell number ( J:175865 )

• reduced numbers

cecum inflammation ( J:175865 )

endocrine/exocrine glands

decreased Paneth cell number ( J:175865 )

• reduced numbers

immune system

cecum inflammation ( J:175865 )

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Ripk3^tm1Vmd/Ripk3^tm1Vmd Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Ripk3^tm1Vmd Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Ripk3^tm1Vmd mutation (1 available); any Ripk3 mutation (31 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:175865 )

N	• mice exhibit normal survival

digestive/alimentary system

digestive/alimentary phenotype ( J:175865 )

N	• mice exhibit normal small intestine and colon morphology

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:175865 )

• 50% of mice die before weaning

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:175865 )

• thickened colon mucosa, ulceration, and altered vascularization

• mucosal edema in the cecum

decreased Paneth cell number ( J:175865 )

• reduced numbers that are not rescued by antibiotic treatment

crypts of Lieberkuhn abscesses ( J:175865 )

intestinal ulcer ( J:175865 )

abnormal cecum morphology ( J:175865 )

• enteritis with blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria

abnormal colon morphology ( J:175865 )

• mice exhibit shorter and thicker colons with thickened colon mucosa, ulceration, and altered vascularization compared with control mice

diarrhea ( J:175865 )

abnormal enterocyte physiology ( J:175865 )

• caspase-independent cell death occurs in the small intestine

increased enterocyte apoptosis ( J:175865 )

• in the colon

abnormal enterocyte proliferation ( J:175865 )

• increased in the colon and cecum

cecum inflammation ( J:175865 )

• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment

colitis ( J:175865 )

• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Fadd^tm1Mpa control mice

• however, colitis is attenuated by treatment with a broad-spectrum antibiotics

growth/size/body

decreased body weight ( J:175865 )

immune system

cecum inflammation ( J:175865 )

• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment

colitis ( J:175865 )

• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Fadd^tm1Mpa control mice

• however, colitis is attenuated by treatment with a broad-spectrum antibiotics

endocrine/exocrine glands

decreased Paneth cell number ( J:175865 )

• reduced numbers that are not rescued by antibiotic treatment

crypts of Lieberkuhn abscesses ( J:175865 )

cellular

increased enterocyte apoptosis ( J:175865 )

• in the colon

abnormal enterocyte proliferation ( J:175865 )

• increased in the colon and cecum

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Tnf^tm1Gkl/Tnf^tm1Gkl Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Tnf^tm1Gkl Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tnf^tm1Gkl mutation (6 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased Paneth cell number ( J:175865 )

• reduced numbers

cecum inflammation ( J:175865 )

colitis ( J:175865 )

• less severe than in Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil-cre)997Gum mice

endocrine/exocrine glands

decreased Paneth cell number ( J:175865 )

• reduced numbers

immune system

cecum inflammation ( J:175865 )

colitis ( J:175865 )

• less severe than in Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil-cre)997Gum mice

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Mlkl^tm1.1Wsa/Mlkl^tm1.1Wsa Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Mlkl^tm1.1Wsa mutation (0 available); any Mlkl mutation (32 available)
Otulin^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:312394 )

N	• normal circulating inflammatory cytokine levels

integument

integument phenotype ( J:312394 )

N	• no skin lesions and normal epidermal thickness

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Ikbkg^tm1.1Mpa mutation (1 available); any Ikbkg mutation (15 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:118336 )

• spontaneous serum ALT levels are decreased compared to single Ikbkg mutants at 8 weeks of age

abnormal enzyme/coenzyme activity ( J:118336 )

• mice show increased JNK kinase activity

immune system

liver inflammation ( J:118336 )

• completely absent compared to single Ikbkg mutants at 8 weeks of age

liver/biliary system

liver/biliary system phenotype ( J:118336 )

N	• liver inflammation, hepatocyte apoptosis, increased hepatocyte proliferation, and focal lipid accumulation are inhibited in mutants compared to Ikbkg single mutants

liver inflammation ( J:118336 )

• completely absent compared to single Ikbkg mutants at 8 weeks of age

cellular

decreased apoptosis ( J:118336 )

• double mutants are protected from LPS-induced hepatocyte apoptosis

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Mog^tm1(cre)Gkl/Mog⁺
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:167475 )

N	• peripheral T cell activation is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:167475 )

• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice

• however, MOG35-55-treated mice exhibit normal T cell activation

nervous system

nervous system phenotype ( J:167475 )

N	• mice exhibit normal myelination

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

cellular

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

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