Analysis Tools
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop colitis
|
|
• reduced numbers
|
|
• reduced numbers
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not develop colitis
|
|
• reduced numbers
|
|
• reduced numbers
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal survival
|
| N |
• mice exhibit normal small intestine and colon morphology
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 50% of mice die before weaning
|
|
• thickened colon mucosa, ulceration, and altered vascularization
• mucosal edema in the cecum
|
|
• reduced numbers that are not rescued by antibiotic treatment
|
|
• enteritis with blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria
|
|
• mice exhibit shorter and thicker colons with thickened colon mucosa, ulceration, and altered vascularization compared with control mice
|
|
• caspase-independent cell death occurs in the small intestine
|
|
• in the colon
|
|
• increased in the colon and cecum
|
|
• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment
|
|
• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Faddtm1Mpa control mice
• however, colitis is attenuated by treatment with a broad-spectrum antibiotics
|
|
• with increased number of granulocytes, blunted and fused villi, mucosal edema, and increased cellularity of the lamina propria that are not rescued by antibiotic treatment
|
|
• as early as 2 weeks of age, mice develop T and B cell infiltration-independent colitis with infiltration of F4/80+, Gr-1+, T, and B cells unlike co-housed Faddtm1Mpa control mice
• however, colitis is attenuated by treatment with a broad-spectrum antibiotics
|
|
• reduced numbers that are not rescued by antibiotic treatment
|
|
• in the colon
|
|
• increased in the colon and cecum
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• reduced numbers
|
|
• reduced numbers
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal circulating inflammatory cytokine levels
|
| N |
• no skin lesions and normal epidermal thickness
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• spontaneous serum ALT levels are decreased compared to single Ikbkg mutants at 8 weeks of age
|
|
|
• mice show increased JNK kinase activity
|
|
|
• completely absent compared to single Ikbkg mutants at 8 weeks of age
|
|
N |
• liver inflammation, hepatocyte apoptosis, increased hepatocyte proliferation, and focal lipid accumulation are inhibited in mutants compared to Ikbkg single mutants
|
|
|
• completely absent compared to single Ikbkg mutants at 8 weeks of age
|
|
|
• double mutants are protected from LPS-induced hepatocyte apoptosis
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• peripheral T cell activation is normal
|
|
• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice
• however, MOG35-55-treated mice exhibit normal T cell activation
|
| N |
• mice exhibit normal myelination
|
|
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice
|
|
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
