Phenotypes associated with this allele

• Allele Symbol: Wnt1^tm1Amc
• Allele Name: targeted mutation 1, Andrew P McMahon
• Allele ID: MGI:3700020
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt1^tm1Amc/Wnt1^tm1Amc	involves: 129S1/Sv * C57BL/6J	MGI:3700027

Genotype
MGI:3700027

hm1

• Allelic Composition: Wnt1^tm1Amc/Wnt1^tm1Amc
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:118582 )

• no homozygous mice are born, but normal Mendelian numbers are observed at E9-10; embryos show defective hindbrain development at E9.5-10.5

nervous system

abnormal hindbrain development ( J:118582 )

• anterior region of hindbrain fails to develop

absent midbrain ( J:118582 )

• region of midbrain fails to develop

absent metencephalon ( J:118582 )

• anterior region of hindbrain fails to develop