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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il22tm1.1Lex
targeted mutation 1.1, Lexicon Genetics
MGI:3699310
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il22tm1.1Lex/Il22tm1.1Lex involves: 129S5/SvEvBrd MGI:4459521
hm2
 		Il22tm1.1Lex/Il22tm1.1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3700050
cn3
 		Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712732
cx4
 		Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712736


Genotype
MGI:4459521
hm1
Allelic
Composition		 Il22tm1.1Lex/Il22tm1.1Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:161073 )
• ranged from 80% to 100% in the second week after infection with C. rodentium

immune system
colitis ( J:161073 )
• an increase in submucosal and transmural inflammation after r C. rodentium infection
abnormal circulating cytokine level ( J:179011 )
• reduced levels of CCL3 and CCL4 after Aspergillus fumigatus infection
decreased circulating interleukin-1 alpha level ( J:179011 )
• after Aspergillus fumigatus infection
decreased circulating interleukin-12 level ( J:179011 )
• after Aspergillus fumigatus infection
decreased circulating interleukin-12b level ( J:179011 )
• after Aspergillus fumigatus infection
increased circulating interleukin-17 level ( J:179011 )
• elevated IL-17A after Aspergillus fumigatus infection
decreased circulating tumor necrosis factor level ( J:179011 )
• after Aspergillus fumigatus infection
lung inflammation ( J:179011 )
• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection
increased susceptibility to bacterial infection induced morbidity/mortality ( J:161073 )
• ranged from 80% to 100% in the second week after infection with C. rodentium
increased susceptibility to fungal infection ( J:179011 )
• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection

growth/size/body
decreased body weight ( J:161073 )
• continue to lose weight after C. rodentium infection

digestive/alimentary system
abnormal large intestine crypts of Lieberkuhn morphology ( J:161073 )
• bacteria penetrate deeply into the colonic crypts after C. rodentium infection
abnormal colon morphology ( J:161073 )
• an increase in mucosal hyperplasia and multiple foci of colonic mucosal ulceration after r C. rodentium infection
colitis ( J:161073 )
• an increase in submucosal and transmural inflammation after r C. rodentium infection

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:161073 )
• bacteria penetrate deeply into the colonic crypts after C. rodentium infection

liver/biliary system
multifocal hepatic necrosis ( J:161073 )
• with embolic microabscessation in the liver following C. rodentium infection

respiratory system
lung inflammation ( J:179011 )
• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection

homeostasis/metabolism
abnormal circulating cytokine level ( J:179011 )
• reduced levels of CCL3 and CCL4 after Aspergillus fumigatus infection
decreased circulating interleukin-1 alpha level ( J:179011 )
• after Aspergillus fumigatus infection
decreased circulating interleukin-12 level ( J:179011 )
• after Aspergillus fumigatus infection
decreased circulating interleukin-12b level ( J:179011 )
• after Aspergillus fumigatus infection
increased circulating interleukin-17 level ( J:179011 )
• elevated IL-17A after Aspergillus fumigatus infection
decreased circulating tumor necrosis factor level ( J:179011 )
• after Aspergillus fumigatus infection

cellular
multifocal hepatic necrosis ( J:161073 )
• with embolic microabscessation in the liver following C. rodentium infection




Genotype
MGI:3700050
hm2
Allelic
Composition		 Il22tm1.1Lex/Il22tm1.1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
ear inflammation ( J:118261 )
• Il-23 induced ear swelling is significantly reduced after Il-23 treatment compared to wild-type
• after Il-23 treatment, mutants have reduced neutrophilic infiltration
abnormal cytokine secretion ( J:118261 )
• Il-22 production is almost absent compared to wild-type

hearing/vestibular/ear
ear inflammation ( J:118261 )
• Il-23 induced ear swelling is significantly reduced after Il-23 treatment compared to wild-type
• after Il-23 treatment, mutants have reduced neutrophilic infiltration

integument
mixed cellular infiltration to dermis ( J:118261 )
• minimal degree of dermal inflammation is observed compared to PBS-treated wild-type mice
thick dermal layer ( J:118261 )
• some dermal hyperplasia is observed compared to PBS-treated wild-type mice
acanthosis ( J:118261 )
• epidermal acanthosis is significantly decreased after Il-23 treatment compared to wild-type




Genotype
MGI:6712732
cn3
Allelic
Composition		 Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased erythroid progenitor cell number ( J:305794 )
• mice show an increase in RII and RIV erythroid precursors compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine
increased erythrocyte cell number ( J:305794 )
• mice exhibit increased numbers of peripheral blood red blood cells compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:305794 )
• mice show alleviation of the stress-induced (via phenylhydrazine treatment) anemia seen in IL-22-sufficient Riok2-haploinsufficent mice




Genotype
MGI:6712736
cx4
Allelic
Composition		 Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased erythrocyte cell number ( J:305794 )
• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:305794 )
• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory