Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp4tm1Jfm mutation
(1 available);
any
Bmp4 mutation
(21 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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normal phenotype
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• mutants show no defects in limb patterning and skeletogenesis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp4tm1Jfm mutation
(1 available);
any
Bmp4 mutation
(21 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
limbs/digits/tail
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• mice exhibit variable penetrance pre- and postaxial syndactyly
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp4tm1Jfm mutation
(1 available);
any
Bmp4 mutation
(21 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
skeleton
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• mice have more severe skeletal defects than Bmp2-heterozygous, Bmp4-homozygous mice, including significantly thinner skeletal elements
• animals do not have abnormal digit patterns
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp4tm1Jfm mutation
(1 available);
any
Bmp4 mutation
(21 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
embryo
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• AER is expanded and maintained much later (>E15.5) than in wild-type
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• at E11.5, limb buds are noticeably broader relative to wild-type
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immune system
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• has not yet started at birth
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limbs/digits/tail
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• interdigital apoptosis is reduced at E15.5
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• AER is expanded and maintained much later (>E15.5) than in wild-type
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• at E11.5, limb buds are noticeably broader relative to wild-type
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• at E15.5 autopod adopts notched pallet form, with only distal tip of each digit separated
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• autopod elements are reduced in size
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• the two posterior-most digits are missing in the forelimbs
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• in newborns, the digits of both forelimb and hindlimb show complete syndactyly
• in the limbs of E15.5 embryos, only the very distal tip of each digit is separated, with the autopod adopting the shape of a notched pallet
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• mice have short and malformed stylopods
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• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
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• mice have short and malformed stylopods
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• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
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skeleton
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• at 3 weeks, all mineralized cartilage in diaphyseal region has disappeared, leaving a void where bone formation should have occurred
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• cavity formation is delayed
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• loss of posterior digits in the forelimbs due to failure of chondrogenesis in this region as indicated by marker analysis
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• joint articulations are defective such that the zeugopod and stylopod elements are fused
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• 1-3 weeks after birth, no bone marrow cavity, trabecular bone, or cortical bone is present
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• at 1-3 weeks after birth , bone formation is not observed in femur for example; skeletal elements in mutants remain similar to E17.5 structures seen in wild-type limbs
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• in E17.5 limbs, delay in endochondral process is observed; bone morphology at birth resembles E17.5 in wild-type
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cellular
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• interdigital apoptosis is reduced at E15.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp7tm1Rob mutation
(2 available);
any
Bmp7 mutation
(37 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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normal phenotype
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• mutants are completely like wild-type in skeletal pattern and differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp7tm1Rob mutation
(2 available);
any
Bmp7 mutation
(37 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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normal phenotype
|
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• mutants are completely like wild-type in skeletal pattern and differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp7tm1Rob mutation
(2 available);
any
Bmp7 mutation
(37 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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skeleton
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• mice show a scapular defect
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp7tm1Rob mutation
(2 available);
any
Bmp7 mutation
(37 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
limbs/digits/tail
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• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb
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• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee
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skeleton
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• overall size of the appendicular skeleton is slightly diminished
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• the last phalanx is missing from digit III in the forelimb and sometimes from the hindlimb
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• fibulae of hindlimbs are malformed and do not articulate with the femur at the knee
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation
(0 available);
any
Bmp2 mutation
(26 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
limbs/digits/tail
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• mice have a variable penetrance of 3/4 soft tissue syndactyly
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skeleton
Analysis Tools
