All Phenotypes Sall4<tm2Ryn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sall4^tm2Ryn
targeted mutation 2, Ryuichi Nishinakamura
MGI:3699176

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall4^tm2Ryn/Sall4^tm2Ryn	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699206
ht2	Sall4^tm2Ryn/Sall4⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699208
cx3	Sall1^tm2Ryn/Sall1⁺ Sall4^tm2Ryn/Sall4⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699211

Allelic Composition	Sall4^tm2Ryn/Sall4^tm2Ryn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4^tm2Ryn mutation (0 available); any Sall4 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:118119 )

• phenotype is stated to be identical to that of Sall4^tm1Ryn homozygotes, however no data is presented in J:118119

embryo

abnormal embryonic tissue morphology ( J:118119 )

abnormal inner cell mass morphology ( J:118119 )

Allelic Composition	Sall4^tm2Ryn/Sall4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4^tm2Ryn mutation (0 available); any Sall4 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:118119 )

postnatal lethality, incomplete penetrance ( J:118119 )

prenatal lethality, complete penetrance ( J:118119 )

• phenotype is stated to be identical to that of Sall4^tm1Ryn homozygotes, however no data is presented in J:118119

digestive/alimentary system

abnormal anus morphology ( J:118119 )

megacolon ( J:118119 )

abnormal rectum morphology ( J:118119 )

cardiovascular system

ventricular septal defect ( J:118119 )

limbs/digits/tail

kinked tail ( J:118119 )

nervous system

exencephaly ( J:118119 )

Allelic Composition	Sall1^tm2Ryn/Sall1⁺ Sall4^tm2Ryn/Sall4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm2Ryn mutation (0 available); any Sall1 mutation (77 available)
Sall4^tm2Ryn mutation (0 available); any Sall4 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:118119 )

• none survive after birth

renal/urinary system

absent kidney ( J:118119 )

• 6 of 38 exhibit bilateral renal agenesis

single kidney ( J:118119 )

• 10 of 38 exhibit unilateral renal agenesis

cardiovascular system

ventricular septal defect ( J:118119 )

• 70% of E17.5-18.5 mutants exhibit ventricular septum defects

digestive/alimentary system

abnormal anus morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

anal stenosis ( J:118119 )

• exhibit anal stenosis at E17.5

abnormal rectum morphology ( J:118119 )

• 68.8% of mutants at E17.5-18.5 exhibit anorectal malformations

nervous system

exencephaly ( J:118119 )

• seen in 44.7% of E13.5-P0 mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23