Sall1^tm2Ryn
Targeted Allele Detail

Summary

• Symbol: Sall1^tm2Ryn
• Name: spalt like transcription factor 1; targeted mutation 2, Ryuichi Nishinakamura
• MGI ID: MGI:2388380
• Synonyms: Sall1-lacZ
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^tm2Ryn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71242
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region, except for sequences encoding the 52 N-terminal amino acids, was deleted and replaced with a lacZ-neomyin resistance cassette. The mutation removes all zinc finger domains from the gene and creates a lacZ fusion protein. Absence of gene expression in homozygous mutant animals was verified by RT-PCR and in situ hybridization. Expression of the lacZ fusion protein was observed by X-gal staining of mutant embryos. (J:71242)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 78 strains or lines available

References

• Original: J:71242 Nishinakamura R, et al., Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development. 2001 Aug;128(16):3105-15
• All: 4 reference(s)