Phenotypes associated with this allele

• Allele Symbol: Gnl3^tm1Rylt
• Allele Name: targeted mutation 1, Robert Y L Tsai
• Allele ID: MGI:3699142
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnl3^tm1Rylt/Gnl3^tm1Rylt	involves: 129X1/SvJ * C57BL/6	MGI:3700778
ht2	Gnl3^tm1Rylt/Gnl3^+	involves: 129X1/SvJ * C57BL/6	MGI:3700779

Genotype
MGI:3700778

hm1

• Allelic Composition: Gnl3^tm1Rylt/Gnl3^tm1Rylt
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:117592 )

• no homozygous embryos are found at E3.5

Genotype
MGI:3700779

ht2

• Allelic Composition: Gnl3^tm1Rylt/Gnl3⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

cellular

abnormal cell cycle ( J:117592 )

• in passages 3 - 5, the number of cells in G2/M increases in heterozygous MEFs but not in wild-type MEFs

increased fibroblast apoptosis ( J:117592 )

• in MEFs in passages 4 and 5

decreased fibroblast proliferation ( J:117592 )

• after passage 3, population doubling level is decreased in heterozygous MEFs compared to wild-type cells

early cellular replicative senescence ( J:117592 )

• from passages 5 through 7, the number of senescent cells is higher in heterozygous compared to wild-type MEFs