All Phenotypes Acvr2b<tm1.1Spo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Acvr2b^tm1.1Spo
targeted mutation 1.1, S Paul Oh
MGI:3697600

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S4/SvJae * FVB/N	MGI:3697595
cx2	Acvr2a^tm1Hsch/Acvr2a⁺ Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S1/Sv * 129S4/SvJae * FVB/N	MGI:3697597
cx3	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo	involves: 129S1/Sv * 129S4/SvJae * FVB/N	MGI:3697598

Allelic Composition	Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2b^tm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

vertebral transformation ( J:114533 )

• only 3 of 21 exhibit vertebral transformation, a significant decrease in the defects seen in Acvr2b^tm1Spo homozygotes

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a⁺ Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2a^tm1Hsch mutation (0 available); any Acvr2a mutation (39 available)
Acvr2b^tm1.1Spo mutation (0 available); any Acvr2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

lumbar vertebral transformation ( J:114533 )

• 6 of 16 exhibit transformation of the 21st vertebra into the 14th thoracic vertebra

embryo

abnormal left-right axis patterning ( J:114533 )

• 12 of 13 show effects associated with left-right asymmetry such as right pulmonary isomerism and transposition of great arteries

cardiovascular system

transposition of great arteries ( J:114533 )

respiratory system

right pulmonary isomerism ( J:114533 )

growth/size/body

right pulmonary isomerism ( J:114533 )

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:114533 )

embryo

embryonic growth arrest ( J:114533 )

• development is arrested at the gastrulation stage (E8.5)

abnormal embryonic tissue morphology ( J:114533 )

• the embryonic tissues grow outside of the yolk sac

embryonic-extraembryonic boundary constriction ( J:114533 )

• exhibit constrictions at the junction between the extraembryonic and embryonic regions at E7.5

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