Phenotypes associated with this allele

• Allele Symbol: Tg(Smgb-TAg)8Mir
• Allele Name: transgene insertion 8, Lily Mirels
• Allele ID: MGI:3696870
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Smgb-TAg)8Mir/Tg(Smgb-TAg)8Mir	involves: BALB/cJ * C57BL/6J	MGI:5009292

Genotype
MGI:5009292

tg1

• Allelic Composition: Tg(Smgb-TAg)8Mir/Tg(Smgb-TAg)8Mir
• Genetic Background: involves: BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal submandibular duct morphology ( J:66189 )

• dysplasia occurs only in cells of intercalated ducts

• gland has multiple aggregates of abnormal ducts and gland-like structures

• abnormal ducts lined by moderately crowded cells with hyperchromatic nuclei are observed in 30 day old mice

• aggregates of hyperplastic/dysplastic ducts are present at 4-6 months of age

• duct lumen is displaced or reduced in size

• no abnormalities are detected in acinar, striated duct or granular convoluted tubule cells

• parotid and sublingual glands are not affected

submandibular gland hyperplasia ( J:66189 )

increased salivary adenocarcinoma incidence ( J:66189 )

• 18 out of 29 (62.1%) male mice develop submandibular gland tumors

• some males develop bilateral tumors

• female mice develop tumors infrequently

• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma

• many tumor cell nuclei are hyperchromatic

• some lesions are undifferentiated, often with a foci of necrosis

• many tumors are unencapsulated, others have broad expansive margins

• dysplasia occurs only in cells of intercalated ducts

endocrine/exocrine glands

abnormal submandibular duct morphology ( J:66189 )

• dysplasia occurs only in cells of intercalated ducts

• gland has multiple aggregates of abnormal ducts and gland-like structures

• abnormal ducts lined by moderately crowded cells with hyperchromatic nuclei are observed in 30 day old mice

• aggregates of hyperplastic/dysplastic ducts are present at 4-6 months of age

• duct lumen is displaced or reduced in size

• no abnormalities are detected in acinar, striated duct or granular convoluted tubule cells

• parotid and sublingual glands are not affected

submandibular gland hyperplasia ( J:66189 )

increased salivary adenocarcinoma incidence ( J:66189 )

• 18 out of 29 (62.1%) male mice develop submandibular gland tumors

• some males develop bilateral tumors

• female mice develop tumors infrequently

• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma

• many tumor cell nuclei are hyperchromatic

• some lesions are undifferentiated, often with a foci of necrosis

• many tumors are unencapsulated, others have broad expansive margins

• dysplasia occurs only in cells of intercalated ducts

neoplasm

increased salivary adenocarcinoma incidence ( J:66189 )

• 18 out of 29 (62.1%) male mice develop submandibular gland tumors

• some males develop bilateral tumors

• female mice develop tumors infrequently

• tumor patterns vary from diffuse to variably defined lobules or discrete nests with a fibrous stroma

• many tumor cell nuclei are hyperchromatic

• some lesions are undifferentiated, often with a foci of necrosis

• many tumors are unencapsulated, others have broad expansive margins

• dysplasia occurs only in cells of intercalated ducts