Phenotypes associated with this allele

• Allele Symbol: Cdh1^tm5(Cdh2)Kem
• Allele Name: targeted mutation 5, Rolf Kemler
• Allele ID: MGI:3696713
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh1^tm5(Cdh2)Kem/Cdh1^tm5(Cdh2)Kem	involves: 129P2/OlaHsd * C57BL/6	MGI:3697487
ht2	Cdh1^tm2Kem/Cdh1^tm5(Cdh2)Kem	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3697488

Genotype
MGI:3697487

hm1

• Allelic Composition: Cdh1^tm5(Cdh2)Kem/Cdh1^tm5(Cdh2)Kem
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:117056 )

• no homozygous embryos are recovered between E5.5 And 7.5; empty deciduae or deciduae filled with cellular debris are observed

embryo

failure of blastocyst to hatch from the zona pellucida ( J:117056 )

• homozygous embryos do not hatch and many cells vacuolize and die

abnormal embryonic tissue morphology ( J:117056 )

• outer cells of blastocyst round up with clearly reduced cell-cell contacts

absent blastocoele ( J:117056 )

• mutant show loosening of cell-cell contacts, form no blastocyst cavity or form small cyst-like cavities when an outer layerseparate from the inner layer

absent trophectoderm ( J:117056 )

• between 3.5 and 4.5 homozygotes cannot form intact trophectoderm

reproductive system

empty decidua capsularis ( J:117056 )

• empty deciduae or deciduae filled with cellular debris are observed

Genotype
MGI:3697488

ht2

• Allelic Composition: Cdh1^tm2Kem/Cdh1^tm5(Cdh2)Kem
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:117056 )

embryo

abnormal trophectoderm morphology ( J:117056 )