Analysis Tools
normal phenotype
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• viable and fertile with no signs of lymphoproliferative disorders
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Allele Symbol Allele Name Allele ID |
Foxp3tm1Tch targeted mutation 1, Talal A Chatila MGI:3696705 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable and fertile with no signs of lymphoproliferative disorders
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median survival is increased to 23 days; however the upper limit of survival span is not increased compared to Foxp3 single hemizygotes
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N |
• normalized levels of IgE
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• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
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• elevated levels of IFNG
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• profoundly impaired production of Th2 cytokines and enhanced production of Th1 cytokines
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N |
• goblet cell metaplasia in the lungs is absent
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• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
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• elevated levels of IFNG
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: survival is longer than in mice on a BALB/c background
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• marked blood eosinophilia
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• lymphocytosis
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• monocytosis
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• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls
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• multisystem lymphoproliferative and myeloproliferative disease similar to mice on a BALB/c background
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• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
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• prominent
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• marked blood eosinophilia
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• lymphocytosis
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• monocytosis
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• hyperimmunoglobulinemia E
• at 23 to 30 days of age, IgE levels are increased by about 4 orders of magnitude compared to littermate controls
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• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
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• prominent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median survival is 16.5 days
(J:117165)
• Background Sensitivity: survival is shorter than in mice on a C57BL/6 background
(J:117165)
• hemizygous males develop lymphoproliferative disease with median survival of ~15 days of age, similar to Foxp3tm3Tch males
(J:120636)
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• massive splenomegaly at 2 weeks of age
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• absence of CD4+ CD25+ regulatory T cells
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• marked blood eosinophilia
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• lymphocytosis
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• marked expansion of CD4+ cell populations
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• marked expansion of CD8+ cell populations
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• significant proportion of CD4+ and CD8+ cell populations are activated
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• monocytosis
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• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
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• hyperimmunoglobulinemia E
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• striking increase in IgG1
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• elevated levels of IFNG
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• elevated levels of IL-10
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• elevated levels of IL-4
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• elevated levels of IL-5
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• elevated levels of IL-6
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• elevated levels of TNFA
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• elevated levels of chemotactic factor monocyte chemotactic protein 1
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• nonselective dysregulated production of both Th1 and Th2 cytokines
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• mixed inflammatory infiltrate containing lymphocytes, neutrophils, monocytes, and eosinophils is found in the liver, stomach, pancreas, and skin
• an eosinophilic and neutrophilic infiltration is found in the gastrointestinal tract
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• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
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• prominent
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• massive splenomegaly at 2 weeks of age
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• absence of CD4+ CD25+ regulatory T cells
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• marked blood eosinophilia
|
|
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• lymphocytosis
|
|
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• marked expansion of CD4+ cell populations
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• marked expansion of CD8+ cell populations
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• significant proportion of CD4+ and CD8+ cell populations are activated
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• monocytosis
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• at 2 weeks of age mice display an intense lymphoproliferative and myeloproliferative disorder
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• hyperimmunoglobulinemia E
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• striking increase in IgG1
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• seen at 2 weeks of age
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• allergic airway inflammation found at 2 weeks of age
• inflammation includes peribronchial infiltrates, goblet cell metaplasia, and mucus impaction
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• goblet cell metaplasia in the lungs
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• seen at 2 weeks of age
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• elevated levels of IFNG
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• elevated levels of IL-10
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• elevated levels of IL-4
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• elevated levels of IL-5
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• elevated levels of IL-6
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• elevated levels of TNFA
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• elevated levels of chemotactic factor monocyte chemotactic protein 1
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• prominent
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• massive splenomegaly at 2 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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