Phenotypes associated with this allele

• Allele Symbol: Il10^tm2Roer
• Allele Name: targeted mutation 2, Axel Roers
• Allele ID: MGI:3696059
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il10^tm2Roer/Il10^tm2Roer Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3696707
cn2	Il10^tm2Roer/Il10^tm2Roer Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3696708

Genotype
MGI:3696707

cn1

• Allelic Composition: Il10^tm2Roer/Il10^tm2Roer; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:117122 )

• 6 hours after LPS injection, TNF, Il12 and Ifng levels are significantly higher than in controls, but less than in Il10^tm1Cgn homozygotes

abnormal inflammatory response ( J:117122 )

• after 3 subcutaneous injections of LPS, mice show an exaggerated inflammatory response similar to response of complete Il10-deficient mice

• 5 days after flank injection of CpG, mice develop moderate belt-shaped lesions similar to controls with no sign of necrosis or granulocyte infiltration

increased susceptibility to endotoxin shock ( J:117122 )

• 6/10 animals died by 2 days post-LPS injection compared to 2/25 controls

Genotype
MGI:3696708

cn2

• Allelic Composition: Il10^tm2Roer/Il10^tm2Roer; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

immune system

abnormal inflammatory response ( J:117122 )

• mice show a moderate local response similar to controls after 3 injections of LPS into the flank

• 5 days after flank injection of CpG, mice develop moderate belt-shaped lesions similar to controls with no sign of necrosis or granulocyte infiltration,

increased susceptibility to endotoxin shock ( J:117122 )

• 9/10 mice survive 48 hour after LPS injection, whereas all completely IL-10-deficient mice die