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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map4k1tm1Tht
targeted mutation 1, Tse-Hua Tan
MGI:3695423
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map4k1tm1Tht/Map4k1tm1Tht B6.129S7-Map4k1tm1Tht MGI:3695606
hm2
 		Map4k1tm1Tht/Map4k1tm1Tht involves: 129S7/SvEvBrd MGI:3695607


Genotype
MGI:3695606
hm1
Allelic
Composition		 Map4k1tm1Tht/Map4k1tm1Tht
Genetic
Background		 B6.129S7-Map4k1tm1Tht
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map4k1tm1Tht mutation (0 available); any Map4k1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:116613 )
• in the experimental autoimmune encephalitis (EAE) model, mutants are more susceptible, demonstrating severe fore- and hindlimb paralysis and greater infiltration of brain tissues by CD4+ T cells than do wild-type animals; T cells proliferate more and produce greater amounts of interferon than wild-type




Genotype
MGI:3695607
hm2
Allelic
Composition		 Map4k1tm1Tht/Map4k1tm1Tht
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map4k1tm1Tht mutation (0 available); any Map4k1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:116613 )
• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type
abnormal humoral immune response ( J:116613 )
• sera in mutants contain more antigen-specific antibodies during primary and secondary immunizations
abnormal cytokine secretion ( J:116613 )
• mutant T cells produce more IL-2 and IL-4, as well as interferon-gamma in vivo in response to keyhole limpet hemocyanin (KLH) stimulation

hematopoietic system
increased T cell proliferation ( J:116613 )
• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type

cellular
increased T cell proliferation ( J:116613 )
• T cells cultured with irradiated splenocytes are hyperproliferative in response to CD3 stimulation
• in absence of costimulation from antigen-presenting cells, stimulation with anti-CD3 and anti-CD28 induces more cell divisions in cultured mutant cells compared to wild-type cells
• in vivo, stimulation with a T cell-dependent antigen, keyhole limpet hemocyanin (KLH) induces more T cell proliferation in mutants than in wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory