Map4k1^tm1Tht
Targeted Allele Detail

Summary

• Symbol: Map4k1^tm1Tht
• Name: mitogen-activated protein kinase kinase kinase kinase 1; targeted mutation 1, Tse-Hua Tan
• MGI ID: MGI:3695423
• Synonyms: HPK1-deficient, Map4k1^-
• Gene: Map4k1 Location: Chr7:28681475-28702704 bp, + strand Genetic Position: Chr7, 16.94 cM, cytoband A3
• Alliance: Map4k1^tm1Tht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116613
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with a neomycin resistance gene. Protein was not detected in immunoblot of mutant spleen or thymus. (J:116613)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k1 Mutation: 53 strains or lines available

References

• Original: J:116613 Shui JW, et al., Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol. 2007 Jan;8(1):84-91
• All: 2 reference(s)